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Mineral metabolism disturbances occur early during the course of chronic kidney disease and eventually affect most patients. For how long such disturbances persist after a successful renal transplantation is mainly unknown. This study will investigate the prevalence of such disturbances in patients more than 10 years following a successful renal transplantation. The patients will be recruited from an existing registry in Norway.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| eGFR >=60ml/min/1.73m2 | Patients with an estimated glomerular filtration rate of >=60 ml/min/1.73m2. | ||
| eGFR 45-60ml/min/1.73m2 | Patients with estimated glomerular filtration rate >=45 ml/min/1.73m2 and <60ml/min/1.73m2. |
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| Measure | Description | Time Frame |
|---|---|---|
| Fibroblast growth factor 23 (FGF23) | To evaluate the long-term effect of a successful renal transplant on this biomarker. | More than 10 years after successful renal transplantation |
| Measure | Description | Time Frame |
|---|---|---|
| Intact parathyroid hormone (iPTH) | To evaluate the long-term effect of a successful renal transplant on this biomarker. | More than 10 years after successful renal transplantation |
| Klotho | To evaluate the long-term effect of a successful renal transplant on this biomarker. |
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Inclusion Criteria:
Exclusion Criteria:
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Patients registered in the Norwegian Renal Registry with transplan more than 10 years ago.
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| Name | Affiliation | Role |
|---|---|---|
| Inger Hjørdis Bleskestad, MD | Helse Stavanger HF | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Stavanger University Hospital | Stavanger | NO-4011 | Norway |
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Blood and urine will be collected along with the clinical observations. Serum, plasma and urine will be frozen for later analyses.
| More than 10 years after successful renal transplantation |
| Neutrophil gelatinase-associated lipocalin (NGAL) | To evaluate the long-term effect of a successful renal transplant on this biomarker. | More than 10 years after successful renal transplantation |