Prevention of Delirium With Light in the Intensive Care Unit

Prevention of Delirium With Light in the Intensive Care Unit

The purpose of this multicenter randomised controlled trial is to investigate if circadian light at the patients bedside (using Philips HealWell system, CE marked)significantly reduces prevalence of delirium in mechanically ventilated intensive care unit patients.

Patients, who are randomly assigned to the "Lightening arm" will have the circadian light for the whole ICU stay. Light levels at the patients bedside will be measured continuously: embedded light sensors provide irradiance and luminous lux recordings in red, green, and blue color bands and a white light measurement in lux

Inclusion Criteria:

• Male and female patients with age 18 years and above
• Intensive Care Unit stay ≥ 48 hours
• Invasive mechanical ventilation or not invasive mechanical ventilation (with positive ventilation pressure >6hours/day and highflow >30 litres) on the day of Intensive Care Unit admission

Exclusion Criteria:

• Patients with a history Intensive Care Unit stay during the actual hospital stay
• Patients with delirium on the day of Intensive Care Unit admission
• Patients with psychiatric diseases
• Patients with a history of stroke and known cognitive dysfunctions
• Participation in other clinical studies 10 days before study inclusion and during the study period
• Psychiatric disease
• History of stroke with known residual cognitive deficits
• History of Asystolia or pulseless electric activity with cardiopulmonary resuscitation during entire hospital stay
• Analphabetism
• Unability of German language use
• Anacusis or Hypoacusis with hearing aid device, Amaurosis
• Allergies to any ingredient of the electrode fixing material
• Lacking willingness to save and hand out data within the study
• Accommodation in an institution due to an official or judicial order
• The informed consent of the patient or the subject's legally acceptable representative can´t be obtained in time
• Patient has a power of attorney or patient's provision, where he/she refuses participation in any clinical trial