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We designed a study to determine whether a single dose of dexmedetomidine or thoracic epidural anesthesia combined with general anesthesia would provide hemodynamic stability, reduce stress hormone responses, inhibit inflammatory cytokine secretion, and improve sleep quality in patients after thoracic surgery.
We designed a prospective, single-blinded, randomized, and controlled study to determine whether a single dose of dexmedetomidine or thoracic epidural anesthesia combined with general anesthesia would provide hemodynamic stability, reduce stress hormone responses, inhibit inflammatory cytokine secretion, and improve sleep quality in patients after thoracic surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| the control group (Group C) | No Intervention | general anesthesia | |
| general anesthesia combined with dexmedetomidine infusion | Experimental | general anesthesia combined with 1 μg/kg dexmedetomidine infusion after induction (Group D) |
|
| general anesthesia combined with TEA | Experimental | general anesthesia combined with TEA (Group E) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| general anesthesia combined with dexmedetomidine infusion | Drug | general anesthesia combined with 1 μg/kg dexmedetomidine infusion after induction (Group D) |
|
| Measure | Description | Time Frame |
|---|---|---|
| inflammatory cytokine secretion and postoperative sleep quality | Primary outcomes were inflammatory cytokine secretion and postoperative sleep quality, which was measured with the BIS data on first and second postoperative nights. | immediately before anesthesia (T1), 5 min after endotracheal intubation (T2), immediately after incision (T3), 5 min after OLV initiation (T4), 5 min after double-lung ventilation initiation (T5), and immediately after extubation (T6) |
| Measure | Description | Time Frame |
|---|---|---|
| amine secretion during the surgical period and hemodynamic stability | amine (epinephrine and norepinephrine) secretion during the surgical period and hemodynamic stability | immediately before anesthesia (T1), 5 min after endotracheal intubation (T2), immediately after incision (T3), 5 min after OLV initiation (T4), 5 min after double-lung ventilation initiation (T5), and immediately after extubation (T6) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hong Ma, M.D.,PhD. | Dept. of Anesthesiology, the First Hospital of CMU | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anesthesiology, the First Hospital of China Medical University | Shenyang | Liaoning | 110001 | China |
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| general anesthesia combined with TEA | Procedure | general anesthesia combined with TEA (Group E) |
|
| ID | Term |
|---|---|
| D013662 | Tea |
| ID | Term |
|---|---|
| D028321 | Plant Preparations |
| D001688 | Biological Products |
| D045424 | Complex Mixtures |
| D001628 | Beverages |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |
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