Multiple-dose Study of Levetiracetam Injection in Japanese and Caucasian Healthy Males

A Single-center, Open-label, Multiple-dose Study to Evaluate the Pharmacokinetics, Safety and Tolerability of Levetiracetam Administered as Intravenous Infusion in Japanese and Caucasian Healthy Male Subjects

To compare the pharmacokinetics of levetiracetam following single and multiple 15-minute intravenous infusions of 1500 mg levetiracetam between Japanese and Caucasian healthy male subjects

Inclusion Criteria:

• healthy Japanese and Caucasian males with the age between 20 and 40 years old,
• with the body mass index between 20 and 25,
• with the body weight between 60 and 80kg

Exclusion Criteria:

• subjects who have a history or presence of drug addiction or excessive use of alcohol
• current smokers and former smokers who have given up since less than 6 months before the first dose
• heavy caffeine drinker