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| Name | Class |
|---|---|
| Korea Health Industry Development Institute | OTHER_GOV |
| Gachon University Gil Medical Center | OTHER |
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The hypothesis of this study is obese patient with Euiiyin-tang for 12 weeks will show a superior reduction compared to those taking the placebo.
This study has two arms, Euiiyin-tang and placebo group. Inclusion of 80 patient each arm. They will be screened at first visit. At the baseline, that is the second visit, they will be evaluated each outcomes including weight, waist circumference, lipid profile (total cholesterol, triglyceride), CRP (C-reactive protein), visceral fat area and subcutaneous fat area using abdominal computed tomography (CT), questionnaires of QoL (Quality of Life) and eating attitudes, etc. The Euiiyin-tang will provide to the patients from the baseline, it contains 4 weeks of serving. After 4 weeks, the visit 3, the evaluation procedure will be repeated except lipid profile, CRP, abdominal CT. Another Euiiyin-tang of 4 weeks will be given to the patient. The visit 4, 4 weeks after the visit 3, the same procedure will be repeated. The visit 5, 12 weeks after from the baseline, the patient will be evaluated including weight, waist circumference, lipid profile, CRP, visceral fat area and subcutaneous fat area using abdominal computed tomography, questionnaires of QoL and eating attitudes, etc.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Euiiyin-tang | Experimental | powder type, 3 times per day before the meal, 12 weeks total |
|
| Placebo | Placebo Comparator | powder type, 3 times per day before the meal, 12 weeks total |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Euiiyin-tang | Drug | Korean medicinal herbal drug |
| |
| Placebo |
| Measure | Description | Time Frame |
|---|---|---|
| Weight reduction | between baseline and 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| C-reactive protein (CRP) | baseline and 12 weeks | |
| Blood pressure | baseline, 4 weeks, 8 weeks, and 12 weeks | |
| Blood glucose |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Yoon-kyung SONG, KMD | Gachon University Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Gachon University Gil Medical Center | Incheon | 405-760 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32507436 | Derived | Cheon C, Song YK, Ko SG. Efficacy and safety of Euiiyin-tang in Korean women with obesity: A randomized, double-blind, placebo-controlled, multicenter trial. Complement Ther Med. 2020 Jun;51:102423. doi: 10.1016/j.ctim.2020.102423. Epub 2020 May 21. | |
| 28637494 | Derived | Cheon C, Jang S, Park JS, Ko Y, Kim DS, Lee BH, Song HJ, Song YK, Jang BH, Shin YC, Ko SG. Euiiyin-tang in the treatment of obesity: study protocol for a randomised controlled trial. Trials. 2017 Jun 21;18(1):289. doi: 10.1186/s13063-017-2039-8. |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| Drug |
Placebo drug, same odor and formula as Euiiyin-tang |
|
| baseline and 12 weeks |
| Waist/hip ratio | 4 weeks, 8 weeks, and 12 weeks |
| Waist circumference | baseline, 4 weeks, 8 weeks, and 12 weeks |
| Korean Obesity-related Quality of Life scale | baseline and 12 weeks |
| Korean version of Eating Attitudes Test-26 | baseline and 12 weeks |
| Total cholesterol | baseline and 12 weeks |
| Triglyceride | baseline and 12 weeks |
| Visceral fat area | Using abdominal computed tomography | baseline and 12 weeks |
| Subcutaneous fat area | Using abdominal computed tomography | baseline and 12 weeks |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |