Transpulmonary Gradient of Inflammation Biomarkers and Pulmonary Vascular Resistance in Acute Respiratory Failure After Cardiac Surgery Under Cardiopulmonary Bypass
Transpulmonary Gradient of Inflammation Biomarkers and Pulmonary Vascular Resistance in Acute Respiratory Failure After Cardiac Surgery Under Cardiopulmonary Bypass
Get a better understanding of the pathophysiological processes of acute respiratory failure following cardiopulmonary bypass to initiate timely therapies targeted on a cell line.
Demonstrate that there is a relationship between increased transpulmonary gradients of inflammation biomarkers (sRAGE, sICAM-1, SPB, PAI-1, ROS) and pulmonary vascular resistance on the one hand and alveolo-capillary gas exchange on the other hand after cardiac surgery under cardiopulmonary bypass.
Inclusion Criteria:
Patient man or woman > 18 y.o.
Patient has signed informed consent prior to the study
Patient affiliated to a social security administration
Patient operated on for cardiac surgery at the University Hospital of Strasbourg.
Patient at high risk for postoperative respiratory failure defined by a SLIP score (Kor et al.) ≥ 22 Kor:
Scheduled use of a pulmonary artery catheter and a left atrial catheter
Exclusion Criteria:
julien.pottecher@chru-strasbourg.fr03 88 12 70 95
Strasbourg, Alsace 67091, France