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| ID | Type | Description | Link |
|---|---|---|---|
| 2010-A00892-37 | Other Identifier | ANSM |
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The number of patients achieved is sufficient to evaluate the diagnostic performance of the test TRAP-myelin
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| Name | Class |
|---|---|
| Institut National de la Santé Et de la Recherche Médicale, France | OTHER_GOV |
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The objective of this project is to characterize the response TRAP positive patients with Multiple Sclerosis (MS) and to evaluate the sensitivity and specificity of the method in order to develop a second time as a diagnostic tool in this disease. We plan to analyze the response TRAP over a hundred patients with various clinical stages SEP (relapsing, progressive forms) and compared to healthy controls,
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Relapsing Multiple Sclerosis- group 1 | Other | Definite multiple sclerosis according to the McDonald criteria, relapsing Patient innocent of thorough treatment or treatment immunomodulator stopped for at least 6 months. |
|
| Relapsing Multiple Sclerosis- group 2 | Other | Multiple sclerosis defined according to the criteria of McDonald, relapsing Patient under treatment immunomodulator for at least 6 months. |
|
| secondary progressive multiple sclerosis- Group 3 | Other | Multiple sclerosis defined according to the criteria of McDonald, secondary progressive multiple sclerosis |
|
| primary progressive multiple sclerosis- group 4 | Other | Multiple sclerosis defined according to the criteria of McDonald, primary progressive multiple sclerosis |
|
| control 1 | Other | healthy volunteers |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Trap Myelin Test | Device |
|
| Measure | Description | Time Frame |
|---|---|---|
| Evaluate the diagnostic performance of myelin-TRAP assay for Multiple Sclerosis | The main criterion corresponds to the area under the curve ROC (Receiver operating characteristic). The curve ROC is a graphic representation of the existing relation between the sensibility and the specificity of a test, calculated for all the values possible thresholds. The performance of the test TRAP-myéline will thus be estimated by means of the area calculated under this curve | 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| Determine the best cut-off rate of myelin-Trap and evaluate the sensitivity and specificity associated | 2 years |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital of Bordeaux | Bordeaux | France | ||||
| Hopital neurologigue Pierre Wertheimer |
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| ID | Term |
|---|---|
| D009103 | Multiple Sclerosis |
| ID | Term |
|---|---|
| D020278 | Demyelinating Autoimmune Diseases, CNS |
| D020274 | Autoimmune Diseases of the Nervous System |
| D009422 | Nervous System Diseases |
| D003711 | Demyelinating Diseases |
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| Control 2 |
| Other |
Patients with central or peripheral neurological non-inflammatory, non-autoimmune. |
|
| Control 3 | Other | Patients having an autoimmune pathology |
|
| Bron |
| France |
| University Hospital of clermont Ferrand | Clermont-Ferrand | France |
| University Hospital of Lille | Lille | France |
| University Hospital of Marseille | Marseille | France |
| University Hospital of Montpellier | Montpellier | France |
| University Hospital of Nantes | Nantes | France |
| University Hospital of Nice | Nice | France |
| University Hospital of Rennes | Rennes | France |
| University Hospital of Strasbourg | Strasbourg | France |
| University Hospital of Toulouse | Toulouse | France |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |