Phase 1 Study of XAF5 Gel Applied to Skin of Healthy Volunteers

A Randomized, Placebo-controlled, Double-blind, Multiple-ascending-dose Study to Assess the Safety and Tolerability of XAF5 Gel Applied to the Skin of Healthy Volunteers

This is a study to assess the safety, tolerability, and pharmacokinetics of XAF5 Gel when applied to the skin of healthy volunteers.

Inclusion Criteria:

• Healthy volunteers
• Must understand and provide informed consent
• Skin upon which a reaction would be visible
• Body weight >= 70 kg

Exclusion Criteria:

• Any active skin disease
• History of skin hypersensitivity
• Clinically significant abnormality on physical exam, ECG, or laboratory tests
• Positive test for HIV, Hepatitis B, or Hepatitis C