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Abnormal vaginal flora is a risk factor for preterm labor. Therefore, in high risk pregnancies for preterm labor the diagnosis and treatment of abnormal flora is indicated. Clindamycin and metronidazole given orally are both acceptable treatments in these cases. The purpose of this study is to compare the effectiveness of Clindamycin Vs metronidazole for the treatment of abnormal vaginal flora in high risk pregnancies. For this purpose, pregnant women who are considered high risk for preterm labor and were diagnosed with abnormal vaginal flora will be randomly treated either with clindamycin or metronidazole. Eradication of the abnormal flora and adverse effects will be monitored and compared
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| clindamycin | Experimental |
| |
| metronidazole | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Clindamycin | Drug | Oral clindamycin 300 Milligrams*2/Day for a week |
| |
| Measure | Description | Time Frame |
|---|---|---|
| To compare the efficacy between oral Clindamycin Vs Metronidazole in the eradication of abnormal vaginal flora | Primary outcome will be assessed by taking a vaginal culture sample a week after one-week antibacterial treatment |
| Measure | Description | Time Frame |
|---|---|---|
| The prevalence of adverse effects | During the antibacterial treatment which is 1 week of therapy | |
| The prevalence of late abortions and preterm deliveries | From date of randomization until the date of delivery or abortion, assessed up to 28 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Zohar Nachum, MD | Departement of obstetric and gynecology, HaEmek medical center, Afula, Israel | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Departement of obstetric and gynecology, Poriya Medical Center | Tiberias | Israel | Israel | |||
| Departement of obstetric and gynecology, HaEmek medical center |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42372950 | Derived | Nachum Z, Soltsman S, Narane A, Lauz N, Petrusyevich T, Wattad M, Colodner R, Peretz A, Yefet E. Oral metronidazole versus clindamycin to treat bacterial vaginosis in pregnancies at risk for preterm labor. Clin Microbiol Infect. 2026 Jun 29:S1198-743X(26)00336-8. doi: 10.1016/j.cmi.2026.06.023. Online ahead of print. |
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| Metronidazole |
| Drug |
Oral metronidazole 500 Milligrams*2/Day for a week |
|
| Assessing the correlation between Nugent score , physical examination and Ph indicators | The outcome is assessed after the diagnosis of abnormal vaginal flora is made at 14-26 weeks of gestation |
| Afula |
| Israel |
| ID | Term |
|---|---|
| D007752 | Obstetric Labor, Premature |
| D016585 | Vaginosis, Bacterial |
| ID | Term |
|---|---|
| D007744 | Obstetric Labor Complications |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D001424 | Bacterial Infections |
| D001423 | Bacterial Infections and Mycoses |
| D007239 | Infections |
| D014627 | Vaginitis |
| D014623 | Vaginal Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D000091662 | Genital Diseases |
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| ID | Term |
|---|---|
| D002981 | Clindamycin |
| D008795 | Metronidazole |
| ID | Term |
|---|---|
| D008034 | Lincomycin |
| D055231 | Lincosamides |
| D011759 | Pyrrolidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D006027 | Glycosides |
| D002241 | Carbohydrates |
| D009593 | Nitroimidazoles |
| D009574 | Nitro Compounds |
| D009930 | Organic Chemicals |
| D007093 | Imidazoles |
| D001393 | Azoles |
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