Assessment of the effect of hyperoxia and hypertonic saline on survival in patients with septic shock Hyperoxia and hypertonic saline may have beneficial effects on organ perfusion and oxygenation and may reduce the organ failure occurences. To date, only scarce data are available. Side effects are not well described. Therefore we designed a randomized clinical trial in order to assess the early administration of hypertonic saline and oxygen in the very early beginning of septic shock.

The study is designed as factorial 2x2. Patients will be stratified at the randomisation according the presence or absence of Acute Respiratory Distress Syndrome in order to perform a sub group analysis for all outcome criteria.

Inclusion Criteria:

• patients with less than 6 hours septic shock according criteria of Bone
• minimal dose of catecholamines at least 0.1 µg/Kg/min
• patient with mechanical ventilation
• written informed consent

Exclusion Criteria:

• age < 18 years
• pregnancy
• participation in other trial with the same endpoint
• moribund
• absence of registration in french health care system
• patient protected by law
• hypernatremia < 130 mmol/l ou > 145 mmol/l
• patient with P/F < 100 mm Hg with PEEP > 5 cms of water
• intracranial hypertension
• patient admitted for cardiac arrest
• overt cardiac failure