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Objectives: Behçet's disease (BD) is a systemic vasculitis. Since vascular endothelial dysfunction plays a prominent role in the pathogenesis of the disease, we considered angiogenic cytokines as an interesting target for investigation in BD. The aim of this study was to investigate the possible role of angiogenin, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in the pathogenesis of BD.
Design and Methods: Sixty five patients with BD and 21 healthy control subjects were included in the study. Serum angiogenin, bFGF and VEGF concentrations were determined by using in vitro enzyme immunoassay (ELISA) kits according to the manufacturer's instructions.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Behçet's patients | Serum levels of angiogenin, bFGF, VEGF levels in Behçet's patients with ocular involvement group, without ocular involvement group and control group |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| serum levels of angiogenin, bFGF, VEGF | Other | Behçet's patients |
|
| Measure | Description | Time Frame |
|---|---|---|
| Serum levels of angiogenin in Behçet's patients with or without ocular involvement | The median serum angiogenin level was significantly higher in all patients with BD than controls (P=0.001). However there was no statistically significant difference between all patients and patients with or without ocular involvement. The mean serum bFGF and the median serum VEGF levels were higher in patients with ocular involvement than all patients, patients without ocular involvement and controls. But these differences did not reach statistical significance. | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Serum levels of bFGF in Behçet's patients with or without ocular involvement | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Serum levels of VEGF in Behçet's patients with or without ocular involvement | 1 year |
Inclusion Criteria:
Exclusion Criteria:
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Turkish patients fulfilling the international diagnostic criteria for Behçet's disease
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| Name | Affiliation | Role |
|---|---|---|
| ali yalçındağ | * Dışkapı Yıldırım Beyazıt Training and Research Hospital, Department of Clinical Biochemistry | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ankara University, Faculty of Medicine, Department of Ophthalmology | Ankara | 06620 | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D001528 | Behcet Syndrome |
| ID | Term |
|---|---|
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D014606 | Uveitis, Anterior |
| D015864 | Panuveitis |
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| ID | Term |
|---|---|
| D042461 | Vascular Endothelial Growth Factor A |
| ID | Term |
|---|---|
| D042442 | Vascular Endothelial Growth Factors |
| D042501 | Angiogenic Proteins |
| D036341 | Intercellular Signaling Peptides and Proteins |
| D010455 | Peptides |
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serum
| D014605 |
| Uveitis |
| D014603 | Uveal Diseases |
| D005128 | Eye Diseases |
| D014657 | Vasculitis |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D056660 | Hereditary Autoinflammatory Diseases |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D012873 | Skin Diseases, Genetic |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D017445 | Skin Diseases, Vascular |
| D000602 | Amino Acids, Peptides, and Proteins |
| D011506 | Proteins |
| D001685 | Biological Factors |