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| Name | Class |
|---|---|
| Canadian Institutes of Health Research (CIHR) | OTHER_GOV |
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In this study the investigators want to look at whether using aspirin instead of rivaroxaban (after initial treatment with rivaroxaban) works as well at preventing blood clots while also reducing risk of bleeding and is more cost effective in patients who have either a total hip replacement or total knee replacement.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| rivaroxaban | Active Comparator | rivaroxaban 10mg x 9 days for total knee arthroplasty patients; x 30 days for total hip athroplasty patients |
|
| ASA | Experimental | ASA 81mg x 9 days for total knee arthroplasty patients; x 30 days for total hip athroplasty patients |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| rivaroxaban and ASA | Drug |
|
| Measure | Description | Time Frame |
|---|---|---|
| symptomatic venous thromboembolism | up to 4 years | |
| major or clinically relevant non-major bleeding | up to 4 years |
| Measure | Description | Time Frame |
|---|---|---|
| survival | up to 4 years | |
| myocardial infarction | up to 4 years | |
| stroke |
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Inclusion Criteria:
1. All patients undergoing elective total hip or knee arthroplasty at the participating institutions will be potentially eligible for this study
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| David R Anderson, MD | Nova Scotia Health Authority | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Capital Health | Halifax | Nova Scotia | B3H 3A7 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29466159 | Derived | Anderson DR, Dunbar M, Murnaghan J, Kahn SR, Gross P, Forsythe M, Pelet S, Fisher W, Belzile E, Dolan S, Crowther M, Bohm E, MacDonald SJ, Gofton W, Kim P, Zukor D, Pleasance S, Andreou P, Doucette S, Theriault C, Abianui A, Carrier M, Kovacs MJ, Rodger MA, Coyle D, Wells PS, Vendittoli PA. Aspirin or Rivaroxaban for VTE Prophylaxis after Hip or Knee Arthroplasty. N Engl J Med. 2018 Feb 22;378(8):699-707. doi: 10.1056/NEJMoa1712746. |
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| ID | Term |
|---|---|
| D054556 | Venous Thromboembolism |
| ID | Term |
|---|---|
| D013923 | Thromboembolism |
| D016769 | Embolism and Thrombosis |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D000069552 | Rivaroxaban |
| ID | Term |
|---|---|
| D013876 | Thiophenes |
| D013457 | Sulfur Compounds |
| D009930 | Organic Chemicals |
| D009025 | Morpholines |
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| up to 4 years |
| wound infection | up to 4 years |
| cost-effectiveness | up to 4 years |
| D010078 |
| Oxazines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |