Effects of IV Administration of Ketamine on the Analgesia Nociception Index (ANI) Measured With the PhysioDoloris

The Effects of Intravenous Administration of Ketamine on the Analgesia Nociception Index (ANI) Measured With the PhysioDoloris Device

This study evaluates effects of the analgesic ketamine on ANI measurements (Anti Nociceptive Index)

Researchers at the University of Washington are doing this study to find out if a commonly used anesthetic affects patients Analgesia Nociception Index (level of pain relief) during abdominal hysterectomy under general anesthesia.

The investigators will administer routine anesthesia care including Ketamine, a commonly used anesthetic, during the patients surgery. During the patients surgery, the investigators will monitor the patients level of pain relief using the PhysioDoloris monitor, which monitors the routinely used EKG monitor. Though not yet FDA approved, the PhysioDoloris is completely non-invasive and collects data from the EKG monitor.

Inclusion Criteria:

• ASA status I, II, or III
• 18 years or older
• Receiving GA with uncomplicated routine intubation
• Ability to provide informed consent
• English-speaking

Exclusion Criteria:

• Presence of coronary artery disease, cardiac arrhythmias, or ketamine allergy
• Patient refusal
• History of substance abuse
• Patients taking psychotropic and/or opiate drugs
• Having a history of psychiatric diseases or psychological problems