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The purpose of this study is to determine if partial breast irradiation administered in a single preoperative fraction is tolerable.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Single Pre-Operative Radiation Therapy | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Single Pre-Operative Radiation Therapy | Radiation | Dose escalation: 3 patients will receive 15 Gy in a single fraction. The following 3 patients will receive 18 Gy. The final 4 patients will receive 20 Gy. |
| Measure | Description | Time Frame |
|---|---|---|
| Acute toxicity | Assess acute toxicity and wound healing complications from the preoperative radiation treatment as per NCI CTCAE Common Toxicity Scale. | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Chronic toxicity | Assess late-onset toxicity associated with a single fraction radiation treatement as per RTOG/EORTC Late Radiation Toxicity Scale | 2 years |
| Cosmetic outcome | Cosmesis will be evaluated as per the EORTC Breast Cancer Cosmetic Rating scale. |
| Measure | Description | Time Frame |
|---|---|---|
| Ipsilateral breast cancer recurrence | 5 years |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Michael Yassa, MD | Maisonneuve-Rosemon Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Maisonneuve-Rosemont Hospital | Montreal | Quebec | H1T 2M4 | Canada |
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| ID | Term |
|---|---|
| D001943 | Breast Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
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| 5 years |
| D017437 |
| Skin and Connective Tissue Diseases |