Single Pre-Operative Radiation Therapy (SPORT) for Low Risk Breast Cancer

The purpose of this study is to determine if partial breast irradiation administered in a single preoperative fraction is tolerable.

Inclusion Criteria:

• Female aged 60 years or older.
• Invasive ductal carcinoma.
• Unifocal disease.
• Tumors less than 2cm.
• No clinical evidence of nodal disease.
• Estrogen receptor status (ER) positive.
• Her2 negative.

Exclusion Criteria:

• Age less than 60 years.
• BRCA 1 and/or BRCA 2 mutation.
• Tumour histology limited to lobular carcinoma only.
• Neoadjuvant hormonal manipulation or chemotherapy.
• More than one primary tumour in different quadrants of the same breast.
• Inability to view tumor on imaging.