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This clinical trial is a multicentric prospective study to assess the clinical and prognostic value of sarcopenia in patients older than 70 years with diffuse large B-cell lymphoma.
Sarcopenia status is assessed by CT scan imaging on the overall survival at 18 months in patients older than 70 years with diffuse large B-cell lymphoma treated by R-CHOP.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| anthropometric measurement | Other | The muscle area assessed by CT scan imaging at a lumbar vertebral landmark (L3) at the time of diagnosis, at the end of treatment, at 12 and 18 months
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| anthropometric measurement | Procedure | To attest the muscular strength: hand grip test, balance test, up and go test |
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| Measure | Description | Time Frame |
|---|---|---|
| progression free survival | at 18 months |
| Measure | Description | Time Frame |
|---|---|---|
| progression free survival | at 24 months | |
| rate of over grade 2 toxicities | at the first and second courses of chemotherapy (day 21 and day 42) | |
| determination of both molecular subtypes GCB and ABC |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Fabrice JARDIN, MD;PhD | Centre Henri Becquerel | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Henri Becquerel | Rouen | 76000 | France |
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| ID | Term |
|---|---|
| D016403 | Lymphoma, Large B-Cell, Diffuse |
| D055948 | Sarcopenia |
| ID | Term |
|---|---|
| D016393 | Lymphoma, B-Cell |
| D008228 | Lymphoma, Non-Hodgkin |
| D008223 | Lymphoma |
| D009370 | Neoplasms by Histologic Type |
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according DASL technology (c-DNA mediated annealing selection extension and ligation) |
| at 24 months |
| D009369 |
| Neoplasms |
| D008232 | Lymphoproliferative Disorders |
| D008206 | Lymphatic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D007160 | Immunoproliferative Disorders |
| D007154 | Immune System Diseases |
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |