Feasibility of an Immediate Preoperative Chemotherapy Before Resection fo Colorectal Cancer

Feasibility of an Immediate Preoperative Chemotherapy Before Resection of Colorectal Cancer and Research of Gene Expressions Changes Induced in the Tumor, Predictive of Chemotherapy Efficiency

The purpose of this study is to analyze the clinical tolerance of immediate preoperative chemotherapy in terms of toxicity and perioperative morbidity and mortality

Inclusion Criteria:

• colorectal metastatic adenocarcinoma (stage IV) with unresectables, measurables and visibles secondary lesions
• primitive tumor must be operate
• patient age between 18 and 70
• OMS status performance < 2
• life expectancy > 12 weeks
• hematologic function : PNN >/= 1.5x10^9/L, platelets >/= 100x10^9/L
• hepatic function : bilirubin </= 1.5xLSN, AST and ALT </= 3xLSN, alcalin phosphatasis </= 3xLSN
• plasmatimic creatin </= 1.25xLSN
• No previous chemotherapy or pelvic radiotherapy
• men and women in age of procreate agreeing to use a contraception until 4 months after the end of treatment for women and until 6 months for men

Exclusion Criteria:

• nonmetastatic forms
• Colorectal tumor which requires preoperative radiotherapy
• nonmeasurable metastasis based on RECIST criteria
• previous chemotherapy for colorectal cancer
• previous irradiation of the primitive tumour
• specific indication against the treatment studied
• Patient considered as inoperable for physiological or carcinologic reasons
• Pregnant or breast feeding women