Web-based Insulin Titration - An Efficacy Study

Web-based Insulin Titration: Improving Diabetes Care in the Netherlands. An Efficacy Study.

The main objective of the study is to determine whether an intensive web-based titration system, called PANDIT (Patient Assisting Net-based Diabetes Insulin Titration), is effective in improving glycaemic control in patients with diabetes mellitus type 2 using a basal insulin, compared to standard care.

Inclusion Criteria:

• Male or female between 18 and 80 years
• Type 2 diabetes mellitus (diagnosed clinically) for ≥ 6 months
• Once daily basal insulin therapy usage
• No restriction on HbA1c or FPG
• BMI < 40 kg/m2
• Ability to read and understand the Dutch language
• Familiarity with the Internet and use of a mobile phone
• Ability and willingness to adhere to the protocol
• Ability and willingness to use a web-based insulin self-titration system
• Confirmed written consent

Exclusion Criteria:

• Type 1 diabetes
• Use of systemic corticosteroid in the last three months
• Recurrent severe hypoglycaemia or hypoglycaemic unawareness
• Active proliferative diabetic retinopathy
• Any clinically significant disease or disorder
• Mental condition rendering the patient unable to understand the nature, scope and possible consequences of the study
• Working in night shifts