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| ID | Type | Description | Link |
|---|---|---|---|
| NL41071.068.12 | Other Identifier | ccmo |
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Blood cardiac troponin T (cTnT) concentration is a widely used marker of acute cardiac injury. Previous research has shown that type 2 diabetic patients may experience large increments in cTnT levels over the subsequent hours following a single bout of moderate-intensity endurance-type exercise. This phenomenon is likely attributed to cardiac ischemia-reperfusion injury caused by reduced nitric oxide (NO) bioavailability. Recent evidence indicates that ingestion of dietary nitrates dramatically increases the bioavailability of NO, and as such, may be protective against cardiac ischemia-reperfusion injury.
The investigators hypothesize that dietary nitrate supplementation blunts the rise in cTnT levels following exercise in type 2 diabetic patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo beverage | Placebo Comparator | the impact of placebo (no active substance) on exercise-induced cTnT release |
|
| Dietary nitrate beverage | Active Comparator | The impact of dietary nitrate (active substance) on exercise-induced cTnT release |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dietary nitrate beverage | Dietary Supplement | ingestion of single dose NaNO3 beverage two hours prior to exercise bout |
|
| Measure | Description | Time Frame |
|---|---|---|
| Cardiac troponin T | Cardiac troponin T levels will be assessed before exercise and over the 6-hour period following a single session of exercise. | 9 hours, hourly time intervals |
| Measure | Description | Time Frame |
|---|---|---|
| Plasma nitrate | Cardiac troponin T levels will be assessed before exercise and over the 6-hour period following a single session of exercise. | 9 hours, hourly time intervals |
| Plasma nitrite | Plasma nitrite levels will be assessed before exercise and over the 6-hour period following a single session of exercise. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jan-Willem van Dijk, MSc | Contact | +31(0)433881394 | janwillem.vandijk@maastrichtuniversity.nl |
| Name | Affiliation | Role |
|---|---|---|
| Luc van Loon, PhD | Maastricht UMC | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Maastricht UMC | Recruiting | Maastricht | 6214 AD | Netherlands |
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| Label | URL |
|---|---|
| research unit | View source |
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| C567316 | Cardiomyopathy, Familial Restrictive, 3 |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| NaCl beverage | Dietary Supplement | ingestion of single dose NaCl beverage two hours prior to exercise bout |
|
| 9 hours, hourly time intervals |
| Blood pressure | Blood pressure will be measured various time during the day. | day |
| D004700 | Endocrine System Diseases |
| D001519 | Behavior |