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Canceled study due to delay of progress procedure and failure to obtain research funds.
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Gastric cancer is still one of the most common malignance in Korea. Because of the popularity of regular check ups, early detection of gastric cancer has increased, consequently, the survival of the patients also has increased. In this reason, the interest of outcomes after gastrectomy for gastric cancer move survival only to quality of life of these patients.
Although the definition of metabolic syndrome is various, but it is normally accepted as a state that insulin resistance or glucose intolerance combined with hypertension or hyperlipidemia or obesity. Metabolic syndrome is a worldwide health problem, and the treatment is modification of life style, weight loss and medication. However, in most of the patients metabolic syndrome is considered not curable disease. Recent studies have shown that some bariatric surgery offers not only control the overweight but also metabolic syndrome. The exact mechanism is still unknown but decreased gastric volume and intestinal bypass itself seemed to play an important role to improve metabolic syndrome over just decreased weight.
For treating gastric cancer, gastrectomy is essential and the extent of gastrectomy is varied subtotal and total gastrectomy according to the location of tumor. Also, reconstruction type is varied gastroduodenostomy and Roux-en-Y gastrojejunostomy after subtotal gastrectomy, esophagojejunostomy after total gastrectomy. This kind of operation for gastric cancer lead decreased gastric volume and/or intestinal bypass, which means this operation could lead similar effect of bariatric surgery. Already, there have been several retrospective reports that metabolic syndrome or diabetes was improved after gastrectomy for gastric cancer but no prospective study about this subject yet in Korea.
The purpose of this study is that evaluating the degree of improvement of metabolic syndrome after gastrectomy for gastric cancer, and analyze the differences between the type of operation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| metabolic syndrome | gastric cancer patients with metabolic syndrome |
| |
| metabolic disease | gastric cancer patients with metabolic disease |
| |
| normal | gastric cancer patients without metabolic syndrome or metabolic disease |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| subtotal gastrectomy with gastroduodenostomy | Procedure |
| ||
| Measure | Description | Time Frame |
|---|---|---|
| the changes of metabolic syndrome | baseline to postoperative 3 month, and there after every 6 months until 24 months after the gastrectomy |
| Measure | Description | Time Frame |
|---|---|---|
| the changes of insulin resistance after gastrectomy | baseline to postoperative 3 month, and there after every 6 months until 24 months after the gastrectomy |
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Inclusion Criteria:
Exclusion Criteria:
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in plan to underwent curative gastrectomy for gastric cancer
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Surgery, Yonsei University Colleage of Medicine, | Seoul | 120-752 | South Korea | |||
| Ji Yeong An |
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| subtotal gastrectomy with Roux-en-Y gastrojejunostomy, |
| Procedure |
|
| total gastrectomy with Rou-en-Y esophagojejunostomy | Procedure |
|
| Seoul |
| 120-752 |
| South Korea |
| Sevrance hospital, Department of General surgery | Seoul | 120-752 | South Korea |
| ID | Term |
|---|---|
| D008659 | Metabolic Diseases |
| D024821 | Metabolic Syndrome |
| D007333 | Insulin Resistance |
| D013274 | Stomach Neoplasms |
| ID | Term |
|---|---|
| D009750 | Nutritional and Metabolic Diseases |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D013272 | Stomach Diseases |
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| ID | Term |
|---|---|
| D015390 | Gastric Bypass |
| ID | Term |
|---|---|
| D050110 | Bariatric Surgery |
| D049088 | Bariatrics |
| D000073319 | Obesity Management |
| D013812 | Therapeutics |
| D005763 | Gastroenterostomy |
| D000714 | Anastomosis, Surgical |
| D013514 | Surgical Procedures, Operative |
| D013505 | Digestive System Surgical Procedures |
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