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| Name | Class |
|---|---|
| Oslo University Hospital | OTHER |
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The purpose of this study is to determine if there are differences in clinical events, i.e bleeding with associated morbidity, if thromboprophylaxis with LMWH (Low Molecular Weight Heparin) is initiated before or after surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| dalteparin 5000IU s.c. | Active Comparator | 5000IU dalteparin s.c. injected the evening before cemented total hip arthroplasty |
|
| saline | Placebo Comparator | Syringes of Saline with the same volume as in the dalteparin injections are injected the evenings before total hip arthroplasty. Dalteparin 5000IU are injected 6 hours after surgery and the concomitant 33 days |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| dalteparin 5000 IU s.c. | Drug | All patients receive injections with either 5000IU dalteparin or saline in the same volume the evening before surgery. All patients receive 5000IU dalteparin 6 hours after surgery and every day from day 2 until day 35. |
| Measure | Description | Time Frame |
|---|---|---|
| total blood loss | measured blood loss during surgery and in wound drains | during and after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| transfusion requirements | number of units packed red blood cells | during and after surgery |
| incidence of bleeding events | excessive bleeding, wound hematoma, wound secretion, other bleeding events |
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Inclusion Criteria:
-patients 50 years or older undergoing cemented total hip arthroplasty for primary osteoarthritis
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Olav Reikeras, MD, Phd | Oslo University Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Martina Hansen's Hospital | Sandvika | Gjettum | 1346 | Norway |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22476844 | Result | Borgen PO, Dahl OE, Reikeras O. Blood loss in cemented THA is not reduced with postoperative versus preoperative start of thromboprophylaxis. Clin Orthop Relat Res. 2012 Sep;470(9):2591-8. doi: 10.1007/s11999-012-2320-9. Epub 2012 Apr 3. |
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| ID | Term |
|---|---|
| D007239 | Infections |
| D006470 | Hemorrhage |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D017985 | Dalteparin |
| ID | Term |
|---|---|
| D006495 | Heparin, Low-Molecular-Weight |
| D006493 | Heparin |
| D006025 | Glycosaminoglycans |
| D011134 | Polysaccharides |
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|
| during and after surgery |
| other complications | all other complications related to surgery | during and after surgery |
| D002241 |
| Carbohydrates |