The purpose is to characterize new hypereosinophilic syndrome biomarkers more informative and more accessible compared to those that we have already thanks to a proteomic approach. This will help the investigators to diagnose the this disease.

Inclusion Criteria:

• dated and signed informed consent
• virale serology negative or negative result less than 6 months
• virale serology negative for HBV or vaccinated patient
• insured
• virale serology negative or negative result less than 6 months
• negative pregnancy test or female menopause for at least 1 year

Exclusion Criteria:

• subject enable adult, under guardianship or under protective measures of justice
• Refusal or inability to give informed consent
• The hypereosinophilic syndrome explained origin other than than atopy, bullous pemphigoid, the Churg-Strauss syndrome and DRESS