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The purpose of this study is to compare the effects of crystalloid and colloid, which are used for pump priming solution, on the microcirculatory alterations during cardiac surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Plasmalyte solution | Active Comparator | Plasmalyte solution infusion to meet the fluid requirements. |
|
| Hextend | Experimental | 6% Hetastarch administeration instead of crystalloids until the total amount given reached 20 ml/kg, which is the maximally allowed daily dose. Afterward, plasmalyte solution infusion to meet the fluid requirements. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| plasmalyte solution | Drug | plasmalyte solution |
| |
| Hextend |
| Measure | Description | Time Frame |
|---|---|---|
| Recovery slope | Recovery slope is a marker of microcirculation. The tissue oxygen saturation (StO2) using InspectraTM StO2 (Hutchinson Technology Inc.,USA) will be recorded continuously. The InspectraTM StO2 probe will be placed on the skin of the thenar eminence and the blood pressure cuff will be wrapped around the arm. After performing vascular occlusion test, the recovery slope will be calculated by the software. | until 2 days after surgery |
| syndecan-1 | marker of glycocalyx degradation | until 2 days after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| lactate | until 2 days after surgery | |
| StO2 (tissue oxygen saturation) | until 2 days after surgery | |
| Cytokine |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Seoul | South Korea |
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| ID | Term |
|---|---|
| D006895 | Hydroxyethyl Starch Derivatives |
| ID | Term |
|---|---|
| D013213 | Starch |
| D004040 | Dietary Carbohydrates |
| D002241 | Carbohydrates |
| D005936 | Glucans |
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| Drug |
Hetastarch administration instead of crystalloids until the total amount given reached 20 ml/kg, which is the maximally allowed daily dose. Afterward, plasmalyte solution infusion to meet the fluid requirements. |
|
Interleukin (IL)-1b, IL-6, IL-8, IL-10, TNF-a |
| until 2 days after surgery |
| D011134 |
| Polysaccharides |