Multicenter Study of Denture Adhesive

Multicenter Randomized Clinical Study of Denture Adhesive to Establish the Guideline

To establish evidence based guidelines for denture adhesives (powder and cream), multicenter cross over randomized clinical trial will be carried out.

The null hypotheses are that there are no difference on improvement from baseline to post application of two adhesives powder and cream, in terms of general satisfaction, oral related quality of life, masticatory function and oral conditions.

This is multicenter study of 10 academic affiliated institutions. The clinical trial will be carried out in randomized allocation at each site, and data will be gathered. The intervention will be 3-arms and center institution (Nihon University) will generate each site random numbers for allocation and each site will follow this randomization. Research protocol had been published at Nihon University and distributed to each site.To survey its protocol compliance, the study meeting will be held periodically (twice an year).

Inclusion Criteria:

• edentulous

Exclusion Criteria:

• Cannot answer the questionnaire
• Deteriorating general conditions
• Maxillofacial defect
• Metal denture user
• Already denture adhesive users
• Severe xerostomia