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Recent experimental and clinical studies have shown that platelets play a critical role in liver ischemia and regeneration. Thrombocytopenia, a frequent and potentially serious condition in liver transplantation (LT) recipients, was shown to be associated with postoperative morbidity and mortality after partial hepatectomy.
The investigators aim at evaluating whether postoperative low platelet counts are indicators of short- and long-term outcomes after liver transplantation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Liver disease and liver transplantation | Patient with end stage liver disease and/or primary liver tumor undergoing liver transplantation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Liver transplantation | Procedure | Standardized technique of liver transplantation Organ procurement follow the rules of the Swiss transplant society |
|
| Measure | Description | Time Frame |
|---|---|---|
| Severe complication after liver transplantation | The severity of complications will be graded according to the Clavien-Dindo classification by outcome. Grade III to V complications will be considered as severe. | 90 days |
| Measure | Description | Time Frame |
|---|---|---|
| Primary graft non-function | Defined as death or retransplantation within the first postoperative week after exclusion of technical, immunological, and infectious causes | first postoperative week |
| Delayed graft function |
| Measure | Description | Time Frame |
|---|---|---|
| Patient survival | 3-year |
Inclusion Criteria:
Exclusion Criteria:
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Patients with end stage liver disease and/or primary liver tumor undergoing liver transplantation
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| Name | Affiliation | Role |
|---|---|---|
| Mickael Lesurtel, M.D., PhD | University of Zurich | Study Director |
| Pierre-Alain Clavien, M.D., PhD | University of Zurich | Study Chair |
| Dimitri A. Raptis, M.D., MSc | University of Zurich | Principal Investigator |
| Emmanuel Melloul, M.D. | University of Zurich | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Zurich, Department of Visceral Surgery and Transplantation | Zurich | Canton of Zurich | 8091 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24123804 | Derived | Lesurtel M, Raptis DA, Melloul E, Schlegel A, Oberkofler C, El-Badry AM, Weber A, Mueller N, Dutkowski P, Clavien PA. Low platelet counts after liver transplantation predict early posttransplant survival: the 60-5 criterion. Liver Transpl. 2014 Feb;20(2):147-55. doi: 10.1002/lt.23759. Epub 2013 Nov 21. |
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| ID | Term |
|---|---|
| D003643 | Death |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D016031 | Liver Transplantation |
| ID | Term |
|---|---|
| D016378 | Tissue Transplantation |
| D064987 | Cell- and Tissue-Based Therapy |
| D001691 | Biological Therapy |
| D013812 | Therapeutics |
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|
Defined as the presence of at least one of the following parameter at 7 days after LT: serum bilirubin > 10 mg/dL and International Normalized Ratio (INR) >1.6 or Alanine aminotransferase serum level (ALT) >2000UI/L
| 7 days after liver transplantation |
| D013505 |
| Digestive System Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
| D016377 | Organ Transplantation |
| D014180 | Transplantation |