Evaluation of PCLs Using Three EUS-FNA Needles

A Multicenter, Prospective, Randomized Study on Endosonographic Evaluation of Pancreatic Cystic Lesions Using 22 G, 19 G, and Flexible 19 G Fine Needle Aspiration

To document impact of EUS-FNA needle size and flexibility on effectiveness of pancreatic cystic lesions (PCL) aspiration, on ability to obtain sufficient material for standard diagnostic testing, and on diagnostic accuracy of EUS-FNA aspirate for differentiation of mucinous (pre-malignant) and non-mucinous cysts.

Inclusion Criteria:

• Pancreatic cystic lesion measuring 13mm or greater in largest diameter.
• Indicated for EUS evaluation of the PCL including EUS-FNA.
• Age 18 years of age or older.
• Willing and able to comply with the study procedures and provide written informed consent form to participate in the study.

Exclusion Criteria:

• Cysts in which FNA is not indicated based on review by the clinician, including potential concern of blood vessel location relative to the cyst.
• Requirement for anticoagulation using clopidogril, warfarin, or other long acting antiplatelet agents (with the exception of aspirin) that cannot be safely stopped according to institutional guidelines.
• Standard contraindications for EUS.
• Known pancreatic pseudocyst.
• Pregnancy.