The purpose of this study is to compare three treatments to see which causes the most weight loss, fat loss, loss of stomach fat and improvement in blood tests like cholesterol.

Three treatments are compared to see which causes the most weight loss, fat loss, loss of stomach fat and improvement in blood tests like cholesterol.

1) Leptin A-200 injections daily with 2 inactive pills taken three times a day, 2) Caffeine with ephedrine pills taken 3 times a day with an inactive injection daily and 3) Both Leptin A-200 injections daily and caffeine with ephedrine pills taken three times a day.

Inclusion Criteria:

• You are healthy.
• You are not pregnant or nursing.
• You are between 18 and 60 years of age.
• You have a body mass index, calculated from your height and weight, of 30 to 40 kg/m2.

Exclusion Criteria:

• You take chronic medications except hormone replacement or contraception.
• You are a woman and are unwilling to use effective contraception during the trial.
• You have blood pressure higher than 150/90.
• You have heart disease.
• You have urinary symptoms from an enlarged prostate.
• You have gained or lost more than 10 pounds in the last 6 months.
• You have used a monoamine oxidase inhibitor medication in the last month.
• You have high or low thyroid function that has not been controlled in the normal range for at least 2 months.
• You have heart disease or a history of stroke.
• You have a known sensitivity to E. coli or E. coli derived products.