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| ID | Type | Description | Link |
|---|---|---|---|
| 1R01DK094475-01A1 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institutes of Health (NIH) | NIH |
| National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | NIH |
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The purpose of this study is to optimize an obesity treatment program targeting overweight 8-12 year old children using "Cue Exposure Training".
The goal of the Cue Exposure program is to train children to resist cues to eat unhealthy foods. Through a series of experimental studies, the investigators will evaluate how many weekly treatment visits there should be, whether children should be exposed to a single food or multiple foods during treatment, whether to use partial reinforcement or not, whether visits should be daily or weekly, and whether the exposures should be in single or multiple contexts. The investigators will be recruiting parent-child dyads in the San Diego community to participate in 8 to 16 weekly or daily treatment sessions either in their home, community center, or our lab, depending on the treatment arm. Parents and children will complete baseline and post-treatment assessments consisting of collecting psychophysiological data, completing laboratory tasks, and completing questionnaires. The investigators will be evaluating which treatment condition reduces overeating (as measured by our laboratory tasks).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Single context | Active Comparator | Subjects will be exposed to food cues in a single context. |
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| Multiple contexts | Experimental | Subjects will be exposed to food cues in multiple contexts. |
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| 8 treatment sessions | Active Comparator | Subjects receive 8 treatment sessions. |
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| 16 treatment sessions | Experimental | Subjects receive 16 treatment sessions |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Single food Cue Exposure Treatment | Behavioral | Subjects will be exposed to the same set of 4 foods in each cue exposure treatment session. |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in overeating (Eating in the absence of hunger) from baseline at an average of 3 months and 6 months | Reduce overeating or eating in the absence of hunger in response to food cues. Habituation to food cues. | Change from baseline at an average of 3 months and 6 months |
| Change in child weight | BMI, BMIz | Change from baseline at an average of 3 and 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change in parent weight from baseline at average of 3 and 6 months | Measured by BMI (Body Mass Index) | Change from baseline at average of 3 and 6 months |
| Change in attention to food cues from baseline at average of 3 and 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Kerri Boutelle, Ph.D. | UCSD | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Center for Health Eating and Activity Research | La Jolla | California | 92037 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22122291 | Background | Boutelle KN, Zucker NL, Peterson CB, Rydell SA, Cafri G, Harnack L. Two novel treatments to reduce overeating in overweight children: a randomized controlled trial. J Consult Clin Psychol. 2011 Dec;79(6):759-71. doi: 10.1037/a0025713. | |
| 12224662 | Background | Epstein LH, Myers MD, Raynor HA, Saelens BE. Treatment of pediatric obesity. Pediatrics. 1998 Mar;101(3 Pt 2):554-70. |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D050177 | Overweight |
| D006963 | Hyperphagia |
| D001835 | Body Weight |
| D063766 | Pediatric Obesity |
| ID | Term |
|---|---|
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D012816 | Signs and Symptoms |
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| Multiple food Cue Exposure Treatment | Behavioral | Subjects will be exposed to a different set of 4 foods in each cue exposure treatment session. |
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| Partial Reinforcement - Enhanced Cue Exposure Treatment | Behavioral | Subjects will take random additional tastes of the food during cue exposure treatment. |
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| Partial Reinforcement -Consistent Cue Exposure Treatment | Behavioral | Subjects will consistently take the same tastes of the food during cue exposure treatment. |
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Reduce attention to food cues, redirect attention to neutral (non-food cues). Measured by computer program measuring response time
| Change from baseline at average of 3 and 6 months |
| Change in impulsivity/Inhibition from baseline at average of 3 and 6 months | Reduce impulsive behavior response to both food and non-food cues. Measured by behavioral tasks | Change from baseline at average of 3 and 6 months |
| Change in psychophysiological measures of responsivity to food cues from baseline at average of 3 and 6 months | Salivation/swallowing using EMG (electromyography), skin conductance, heart rate and heart rate variability. | Change from baseline at average of 3 and 6 months |
| Change in level of self-reported cravings in response to palatable food cues from baseline at average of 3 and 6 months | Participants will rate their cravings on a scale of 1-10. | Change from baseline at average of 3 and 6 months |
| 10896760 | Background | Nederkoorn C, Smulders FT, Jansen A. Cephalic phase responses, craving and food intake in normal subjects. Appetite. 2000 Aug;35(1):45-55. doi: 10.1006/appe.2000.0328. |
| 15001020 | Background | Nederkoorn C, Jansen A. Cue reactivity and regulation of food intake. Eat Behav. 2002 Spring;3(1):61-72. doi: 10.1016/s1471-0153(01)00045-9. |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012817 | Signs and Symptoms, Digestive |