The Effect of Administration of Low Dose Adrenaline During Surgery on Bleeding During Hip Surgery

The Effect of Intraoperative Low Dose Adrenaline on Bleeding in Total Hip Arthroplasty - a Randomized Placebo-controlled Trial

The purpose of this study is to evaluate the effect of intraoperative administration of low-dose adrenaline on intraoperative blood loss in patients undergoing hip surgery.

Hip arthroplasty is associated with bleeding, anemia and the need for allogeneic transfusion. Administration of low-dose adrenaline activates the coagulation system and may decrease intraoperative and immediate postoperative bleeding. Thus, the aim of this study is to evaluation whether intraoperative IV-administration of low-dose adrenaline reduces bleeding in elective total hip arthroplasty.

Inclusion Criteria:

• Age > 18 years.
• Scheduled for primary unilateral hip arthroplasty
• Able to give consent

Exclusion Criteria:

• Allergy towards adrenaline
• Current treatment with: ADP receptor inhibitors or Vitamin K antagonists (within 5 days), Factor Xa inhibitors or Thrombin inhibitors (within 1 day), heparin (excluding low molecular weight heparin for perioperative thromboprophylaxis).
• Current treatment with tricyclic antidepressants
• Use of MAO inhibitors (within previous 14 days) or COMT inhibitors (within 2 days).
• Acute coronary syndrome / myocardial infarction within the previous 6 months.
• not willing to accept blood transfusion
• Participation in other clinical trial within previous 30 days
• Women of childbearing age (without menopause for at least 12 months)
• Glaucoma
• Pheochromocytoma
• Low serum K+ (< 3.0 mmol/L)
• Thyrotoxicosis
• Digoxin intoxication
• Alcohol og drug abuse (investigators judgement)