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Fat tissue from omenta, thigh and abdomen taken under anesthesia on subjects undergoing laparoscopic surgery, cholecystectomy, reflux surgery or gastric by-pass (GBP).
Are there any difference in polymorphids and/or mRNA expression in genes significant for developing obesity, between normal weight and obese individuals, with or without diabetes typ 2 .
Are there any difference in polymorphids and/or mRNA expression in different types of fat tissue
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Type 2 Diabetes and BMI>35 | Patients with type 2 diabetes and body mass index 35 or more. | ||
| BMI>35 | Patients undergoing surgery, gastric bypass or cholecystectomy, without diabetes type 2 and body mass index 35 or more | ||
| BMI 18-27 | Patients undergoing surgery, cholecystectomy or reflux, without type 2 diabetes and body mass index between 18-27 |
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| Measure | Description | Time Frame |
|---|---|---|
| Differences in polymorphids and/or mRNA expression in genes, significant for developing obesity and type 2 diabetes, between patients with normal weight and obesity | fat biopsy taken from abdomen, omenta and thigh at surgery | approximatly 30 minutes after start of operation |
| Difference in polymorphids and/or mRNA expression in different types of fat tissue in patients with normal weight or obesity with or without diabetes type 2 | fat biopsy; abdomen, omenta and thigh taken at surgery | approximatly 30 minutes after start of operation |
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Inclusion Criteria:
Exclusion Criteria:
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Tree groups; group I: diabetes type II with BMI>35 Group II: no diabetes BMI>35 Group III: no diabetes BMI 18-27
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| Name | Affiliation | Role |
|---|---|---|
| Anders Thorell, Ass. prof. | Karolinska Institutet | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ersta hospital | Stockholm | Stockholm County Council | 116 91 | Sweden | ||
| Karolinska Institutet, CMM |
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biopsys; Fat from oment, thigh and abdomen
| Stockholm |
| 171 76 |
| Sweden |