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The purpose of this study is to compare the number of responders to vaccination with the influenza virus vaccine at different time points after last dose of rituximab in patients with lymphoma. Secondly to study the immune-response to vaccination with influenza virus vaccine, after treatment with rituximab in relation to the reconstitution of immune-function.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Early group after rituximab | Active Comparator | Patients who received rituximab last dose 3-6 months before influenza vaccination will be the "early group". |
|
| Late group after rituximab | Active Comparator | Patients who received rituximab last dose 9-12 months before influenza vaccination will be the "late group". |
|
| Control group | Active Comparator | Healthy individuals will be receive vaccination with influenza vaccine and will serve as controls. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| influenza vaccination with influenza vaccine | Biological |
|
| Measure | Description | Time Frame |
|---|---|---|
| Influenza antibody titre | 3 weeks after vaccination |
| Measure | Description | Time Frame |
|---|---|---|
| number of memory B cells | 6 months | |
| lymphocyte subsets | 6 months | |
| immunoglobulin levels |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Minke AE Rab, Drs. | St. Antonius Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Canisius Wilhelmina Hospital | Nijmegen | Gelderland | Netherlands | |||
| Onze Lieve Vrouwen Gasthuis |
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| ID | Term |
|---|---|
| D008228 | Lymphoma, Non-Hodgkin |
| D007251 | Influenza, Human |
| ID | Term |
|---|---|
| D008223 | Lymphoma |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D008232 | Lymphoproliferative Disorders |
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| ID | Term |
|---|---|
| D007252 | Influenza Vaccines |
| C568705 | influvac |
| C478242 | vaxigrip |
| ID | Term |
|---|---|
| D014765 | Viral Vaccines |
| D014612 | Vaccines |
| D001688 | Biological Products |
| D045424 | Complex Mixtures |
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| 6 months |
| IgG subclasses | 6 months |
| production of IFN-γ by CD4+ cells | 6 months |
| Cytokines | 6 months |
| genetic factors | 6 months |
| Amsterdam |
| North Holland |
| Netherlands |
| Medisch Spectrum Twente | Enschede | Overrijssel | Netherlands |
| Medisch Centrum Leeuwarden | Leeuwarden | Provincie Friesland | Netherlands |
| Reinier de Graaf Groep | Delft | South Holland | Netherlands |
| Albert Schweitzer Hospital | Dordrecht | South Holland | Netherlands |
| St. Antonius Hospital | Nieuwegein | Utrecht | 3435CM | Netherlands |
| D008206 |
| Lymphatic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D007160 | Immunoproliferative Disorders |
| D007154 | Immune System Diseases |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D009976 | Orthomyxoviridae Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
| D012140 | Respiratory Tract Diseases |