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The present study will evaluate the long term effects on scar formation for dermatome-induced skin wounds treated with Collagenase Santyl® Ointment or vehicle (white petrolatum ointment) alone. The previous study, 017-101-09-001, utilized a small, experimental, cutaneous wound to evaluate both time to complete wound closure and quality of the resulting scar when Collagenase Santyl® Ointment was used to treat the wound.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Assessment | All subjects will receive same assessments. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Santyl | Biological |
|
| Measure | Description | Time Frame |
|---|---|---|
| Scar Assessment | Vancouver Scar Scale assessment of dermatome wounds previously treated with Santyl Ointment or White Petrolatum | 1 Day |
| Measure | Description | Time Frame |
|---|---|---|
| Scar Quality | Quality of scars over time will be assessed with the BTC-2000 instrument assessment | 1 Day |
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Inclusion Criteria:
Exclusion Criteria:
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Healthy adult volunteers who were previously treated in study 017-101-09-001 with Collagenase Santyl Ointment and Vehicle (white petrolatum ointment).
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| Name | Affiliation | Role |
|---|---|---|
| Herbert B Slade, MD | Healthpoint | Study Chair |
| Shai Rozen, MD | University of Texas Southwestern Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dallas | Texas | 75390 | United States |
| Type | Date | Date Unknown |
|---|---|---|
| Release | Sep 13, 2016 | |
| Reset | Oct 31, 2016 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Sep 13, 2016 | Oct 31, 2016 |
| ID | Term |
|---|---|
| D002921 | Cicatrix |
| ID | Term |
|---|---|
| D005355 | Fibrosis |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D017364 | Collagenases |
| ID | Term |
|---|---|
| D008666 | Metalloendopeptidases |
| D010450 | Endopeptidases |
| D010447 | Peptide Hydrolases |
| D006867 | Hydrolases |
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| D004798 |
| Enzymes |
| D045762 | Enzymes and Coenzymes |
| D045726 | Metalloproteases |