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This retrospective study will evaluate the association of biomarkers and the treatment response of patients with chronic hepatitis B, who have completed therapy with Pegasys (peginterferon alfa-2a) ± lamivudine. For the analysis stored serum samples obtained from patients will be used; no actual patients are involved.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cohort |
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| Measure | Description | Time Frame |
|---|---|---|
| Interleukin-28B (IL-28B) genotype in stored serum samples of patients with chronic hepatitis B, who have completed therapy with Pegasys +/- lamivudine | Samples up to 72 weeks of treatment | |
| Single nucleotide polymorphisms (SNP) of rs12356193 in stored serum samples of patients with chronic hepatitis B, who have completed therapy with Pegasys +/- lamivudine | Samples up to 72 weeks of treatment |
| Measure | Description | Time Frame |
|---|---|---|
| IL-28B concentration at baseline and during treatment with Pegasys +/- lamivudine from stored serum samples of patients with chronic hepatitis B | Samples up to 72 weeks of treatment | |
| Protein/RNA biomarker evaluation from stored serum samples of patients with chronic hepatitis B, who have completed therapy with Pegasys +/- lamivudine |
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Inclusion Criteria:
Exclusion Criteria:
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Stored serum samples obtained from patients with chronic hepatitis B, who have completed therapy with Pegasys +/- lamivudine.
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| Name | Affiliation | Role |
|---|---|---|
| Clinical Trials | Hoffmann-La Roche | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Herston | Queensland | 4006 | Australia | |||
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29741634 | Derived | van Bommel F, van Bommel A, Krauel A, Wat C, Pavlovic V, Yang L, Deichsel D, Berg T, Bohm S. Serum HBV RNA as a Predictor of Peginterferon Alfa-2a Response in Patients With HBeAg-Positive Chronic Hepatitis B. J Infect Dis. 2018 Aug 24;218(7):1066-1074. doi: 10.1093/infdis/jiy270. |
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| Samples up to 72 weeks of treatment |
| Fitzroy |
| Victoria |
| 3065 |
| Australia |
| Clichy | 92118 | France |
| Hong Kong | 852 | Hong Kong |
| Hong Kong | Hong Kong |
| Bari | Apulia | 70124 | Italy |
| Brescia | Lombardy | 25123 | Italy |
| Cagliari | Sardinia | 09042 | Italy |
| Pisa | Tuscany | 56124 | Italy |
| Auckland | 100 | New Zealand |
| Hamilton | New Zealand |
| Saint Petersburg | 190103 | Russia |
| Samara | 443011 | Russia |
| Stavropol | 355017 | Russia |
| Singapore | 169608 | Singapore |
| Singapore | 228510 | Singapore |
| Seoul | 03080 | South Korea |
| Seoul | 120-752 | South Korea |
| Seoul | 138-736 | South Korea |
| Kaohsiung City | 807 | Taiwan |
| Taipei | 100 | Taiwan |
| Taoyuan | 333 | Taiwan |
| Bangkok | 10400 | Thailand |
| Bangkok | 10700 | Thailand |
| Chiang Mai | 50202 | Thailand |
| Khon Kaen | 40002 | Thailand |
| Songkhla | 90112 | Thailand |
| ID | Term |
|---|---|
| D019694 | Hepatitis B, Chronic |
| ID | Term |
|---|---|
| D006509 | Hepatitis B |
| D000086982 | Blood-Borne Infections |
| D003141 | Communicable Diseases |
| D007239 | Infections |
| D018347 | Hepadnaviridae Infections |
| D004266 | DNA Virus Infections |
| D014777 | Virus Diseases |
| D006525 | Hepatitis, Viral, Human |
| D006521 | Hepatitis, Chronic |
| D006505 | Hepatitis |
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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