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| Name | Class |
|---|---|
| Lund University | OTHER |
| Folkhalsan Research Center | UNKNOWN |
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The effect of 3 months of melatonin 4mg treatment on glucose tolerance in different variants of the melatonin receptor 1B gene will be evaluated. The following will be done at 0 and 3 months:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Melatonin | Experimental | melatonin 4mg od for 3 months |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Melatonin | Drug | All subjects receive the same dose of melatonin |
|
| Measure | Description | Time Frame |
|---|---|---|
| Glucose tolerance | Glucose tolerance is measured in OGTT: 0,30,60,90 and 120 minute values of glucose and insulin. | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| sleep | monitoring of sleep with questionnaires and activity monitoring | 3 months |
| Activity | Activity and sleep of the subjects is recorded with Actigraph at 0 and 3 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Leif Groop, Prof. | University of Lund, University of Helsinki | Study Chair |
| Tiinamaija Tuomi, Docent | Helsinki University Central Hospital | Study Director |
| Bo Isomaa, Docent | Folkhalsan | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Botniacentret Jakobstad | Jakobstad | 68660 | Finland | |||
| Vasa health care centre |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27185156 | Result | Tuomi T, Nagorny CLF, Singh P, Bennet H, Yu Q, Alenkvist I, Isomaa B, Ostman B, Soderstrom J, Pesonen AK, Martikainen S, Raikkonen K, Forsen T, Hakaste L, Almgren P, Storm P, Asplund O, Shcherbina L, Fex M, Fadista J, Tengholm A, Wierup N, Groop L, Mulder H. Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes. Cell Metab. 2016 Jun 14;23(6):1067-1077. doi: 10.1016/j.cmet.2016.04.009. Epub 2016 May 12. |
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| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
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| ID | Term |
|---|---|
| D008550 | Melatonin |
| ID | Term |
|---|---|
| D014363 | Tryptamines |
| D007211 | Indoles |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
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| 3 months |
| Vaasa |
| 65200 |
| Finland |
| D006571 | Heterocyclic Compounds |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |