Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The investigators intend to assess the role of several biomarkers in the prediction of relapse in IBD. Clinical, laboratory and endoscopic data will be gathered and a predictive score will be derived in order to assess the relapse risk at 1 year.
Patients with a confirmed diagnosis of IBD will be prospectively assessed on a yearly basis in order to assess relapse risk factors.
Disease activity will be assessed using the Mayo score for UC patients and CDAI for Crohn's disease and endoscopic activity will be assessed using the Mayo endoscopic subscore for UC patients and the Simple Endoscopic Score for Crohn's Disease for CD patients.
Serum and fecal biomarkers will be obtainted at each study visit (C-reactive protein, fecal calprotectin).
Data about current and past medication for IBD will also be gathered.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| IBD patients | patients with ulcerative colitis or crohn's disease, in remission |
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| Clinical relapse | clinical relapse as assessed by conventional scores for activity in IBD - Mayo or CDAI | 1 year |
| Prevalence of NAFLD | to assess the prevalence of nonalcoholic liver disease in IBD patients | 1 year |
| prevalence of vitamin D deficiency | to assess vitamin D deficiency and osteopenia among IBD patients | 1 year |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
all patients with IBD over 18 years of age, currently in clinical remission
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Theodor A Voiosu, MD | Contact | 0040726732764 | theodor.voiosu@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Theodor Voiosu, Md | Clinical Hospital Colentina | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Colentina Clinical Hospital | Recruiting | Bucharest | 020125 | Romania |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 9246063 | Background | Dionne S, Hiscott J, D'Agata I, Duhaime A, Seidman EG. Quantitative PCR analysis of TNF-alpha and IL-1 beta mRNA levels in pediatric IBD mucosal biopsies. Dig Dis Sci. 1997 Jul;42(7):1557-66. doi: 10.1023/a:1018895500721. | |
| 25267955 | Derived | Voiosu T, Bengus A, Dinu R, Voiosu AM, Balanescu P, Baicus C, Diculescu M, Voiosu R, Mateescu B. Rapid fecal calprotectin level assessment and the SIBDQ score can accurately detect active mucosal inflammation in IBD patients in clinical remission: a prospective study. J Gastrointestin Liver Dis. 2014 Sep;23(3):273-8. doi: 10.15403/jgld.2014.1121.233.thv. |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D003093 | Colitis, Ulcerative |
| D003424 | Crohn Disease |
| D065626 | Non-alcoholic Fatty Liver Disease |
| D014808 | Vitamin D Deficiency |
| ID | Term |
|---|---|
| D003092 | Colitis |
| D005759 | Gastroenteritis |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
serum and fecal samples
| D015212 |
| Inflammatory Bowel Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D005234 | Fatty Liver |
| D008107 | Liver Diseases |
| D001361 | Avitaminosis |
| D003677 | Deficiency Diseases |
| D044342 | Malnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |