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This trial is conducted in Europe. The aim of this trial is to compare the efficacy of repaglinide to glyburide and placebo on hepatic glucose metabolism in subjects with type 2 diabetes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Treatment period 1 | Experimental |
| |
| Treatment period 2 | Active Comparator |
| |
| Treatment period 3 | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| repaglinide | Drug | 1 mg before each main meal on three separate dosing visits separated by a wash-out period |
|
| Measure | Description | Time Frame |
|---|---|---|
| Basal hepatic glucose production | Day 0; day 44 |
| Measure | Description | Time Frame |
|---|---|---|
| Number of hypoglycaemic episodes | Day 0; day 44 | |
| Change in body weight | Day 0; day 44 | |
| Number of adverse events |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Global Clinical Registry (GCR, 1452) | Novo Nordisk A/S | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Novo Nordisk Investigational Site | Padova | 35137 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| Result | Ciccarone A, Mari A, Pulizzi N, Bianchi C, Palumbo F, Benzi L, Del Prato S. Assessment of insulin secretion in response to a mixed meal in type 2 diabetes. Effects of short-term repaglinide and glibenclamide administration. Diabetologia 2005; 48 (Suppl. 1): A284 (Abstract No. PS65-781) |
| Label | URL |
|---|---|
| Clinical Trials at Novo Nordisk | View source |
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| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
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| ID | Term |
|---|---|
| C072379 | repaglinide |
| D005905 | Glyburide |
| ID | Term |
|---|---|
| D013453 | Sulfonylurea Compounds |
| D014508 | Urea |
| D000577 | Amides |
| D009930 | Organic Chemicals |
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| glyburide | Drug | 5 mg before breakfast and before supper on three separate dosing visits separated by a wash-out period |
|
| placebo | Drug | Before each main meal on three separate dosing visits separated by a wash-out period |
|
| Day 0; day 44 |
| D013450 |
| Sulfones |
| D013457 | Sulfur Compounds |