Test bioequivalence of generic tacrolimus (Tacni), using original tacrolimus (Prograf) as comparator, in elderly (>60 yr) renal transplant recipients

12-hour pharmacokinetic investigations performed on each formulation in each patient at steady-state. Patients will be randomized with regards to which formulation to start with. 1-2 weeks between each PK investigation.

Inclusion Criteria:

• Renal transplant recipients that will receive Tac as part of their immunosuppressive therapy.
• Recipients 60 years of age or older.
• Signed informed consent.

Exclusion Criteria:

• Diabetes mellitus (WHO criteria).
• Concomitant treatment with: diltiazem, verapamil, phenytoin, carbamazepin, fluconazole, ketoconazole, voriconazole, erythromycin, clarithromycin.