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| Name | Class |
|---|---|
| National Institute for Medical Research, Tanzania | OTHER_GOV |
| Kilimanjaro Christian Medical Centre, Tanzania | OTHER |
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The study is a cluster randomised trial to compare the effectiveness of indoor residual spraying (IRS) combined with the use of long lasting insecticidal nets (LLINs) with the effectiveness of LLINs alone for preventing malaria infection and morbidity. The primary outcome measure is prevalence of parasitaemia and anaemia in children aged 0.5-10 years, measured in cross sectional surveys. Secondary outcomes include relative population density for each mosquito vector species, malaria transmission as measured by entomological inoculation rates (EIR) by mosquito vector species, monitoring of resistance markers including kdr, and user acceptability of LLINs compared with IRS.
Findings from this study are expected to inform decision making so that resource utilization can be optimised.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| LLIN plus IRS | Experimental | LLIN by universal coverage campaign 2 rounds of indoor residual spraying with bendiocarb insecticide |
|
| LLIN only | Active Comparator | LLIN by universal coverage campaign |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Indoor residual spraying with bendiocarb | Other | 2 rounds of indoor residual spraying with bendiocarb insecticide, 4 months apart |
|
| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of malarial infection in children 6 months to 10 years | 9 months post randomisation |
| Measure | Description | Time Frame |
|---|---|---|
| Moderate to severe anaemia in children under 5 years | 9 months post randomisation | |
| Post-spraying prevalence of infection with malarial parasites in children 6 months to 10 years | 6 months post randomisation |
| Measure | Description | Time Frame |
|---|---|---|
| Entomological Innoculation Rate | Malaria season post randomisation(Average value during 6 months after randomisation) | |
| Relative abundance of adult Anopheles mosquitoes by species | Malaria season post randomisation (Average value during 6 months after randomisation) |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mark Rowland, PHD | Contact | Mark.Rowland@lshtm.ac.uk | ||
| Immo Kleinschmidt, PHD | Contact | Immo.Kleinschmidt@lshtm.ac.uk |
| Name | Affiliation | Role |
|---|---|---|
| Mark Rowland, PHD | London School of Hygiene and Tropical Medicine | Principal Investigator |
| Immo Kleinschmidt, PHD | London School of Hygiene and Tropical Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| PAMVERC office | Recruiting | Muleba | Kagera | Tanzania |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19706925 | Background | Kleinschmidt I, Schwabe C, Shiva M, Segura JL, Sima V, Mabunda SJ, Coleman M. Combining indoor residual spraying and insecticide-treated net interventions. Am J Trop Med Hyg. 2009 Sep;81(3):519-24. | |
| 22882836 | Result | West PA, Protopopoff N, Rowland MW, Kirby MJ, Oxborough RM, Mosha FW, Malima R, Kleinschmidt I. Evaluation of a national universal coverage campaign of long-lasting insecticidal nets in a rural district in north-west Tanzania. Malar J. 2012 Aug 10;11:273. doi: 10.1186/1475-2875-11-273. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Jun 4, 2014 | |
| Reset | Jul 3, 2014 |
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| LLIN by universal coverage campaign | Other | Long lasting Insecticide treated mosquito net |
|
|
| genotypic markers of insecticide resistance in malaria vector mosquitoes | Malaria season post randomisation (Average value during 6 months after randomisation) |
| 25811379 | Derived | West PA, Protopopoff N, Wright A, Kivaju Z, Tigererwa R, Mosha FW, Kisinza W, Rowland M, Kleinschmidt I. Enhanced protection against malaria by indoor residual spraying in addition to insecticide treated nets: is it dependent on transmission intensity or net usage? PLoS One. 2015 Mar 26;10(3):e0115661. doi: 10.1371/journal.pone.0115661. eCollection 2015. |
| 24736370 | Derived | West PA, Protopopoff N, Wright A, Kivaju Z, Tigererwa R, Mosha FW, Kisinza W, Rowland M, Kleinschmidt I. Indoor residual spraying in combination with insecticide-treated nets compared to insecticide-treated nets alone for protection against malaria: a cluster randomised trial in Tanzania. PLoS Med. 2014 Apr 15;11(4):e1001630. doi: 10.1371/journal.pmed.1001630. eCollection 2014 Apr. |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Jun 4, 2014 | Jul 3, 2014 |
| ID | Term |
|---|---|
| D008288 | Malaria |
| ID | Term |
|---|---|
| D011528 | Protozoan Infections |
| D010272 | Parasitic Diseases |
| D007239 | Infections |
| D000096724 | Mosquito-Borne Diseases |
| D000079426 | Vector Borne Diseases |
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| ID | Term |
|---|---|
| C007725 | bendiocarb |
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