The purpose of this study is to determine whether acupuncture or moxibustion therapies are effective in the treatment of active Crohn's disease. meanwhile, we are aim to observe the content of Inflammatory factors and Neurotransmitter before and after acupuncture and moxibustion therapy.

The purpose of this study is to determine whether acupuncture or moxibustion therapies are effective in the treatment of active Crohn's disease. meanwhile, we are aim to observe the content of Inflammatory factors and Neurotransmitter before and after acupuncture and moxibustion therapy.

Through treating active Crohn's disease by acupuncture and moxibustion therapies for 12 weeks, we are aim to observe the efficiency and the probably change of Inflammatory factors and Neurotransmitter of colonic mucosa and we may elucidate the mechanism of the efficiency of acupuncture and moxibustion therapy.

Inclusion Criteria:

• age 18-70 years;
• Crohn's Disease Activity Index [CDAI]>150 and <450;
• not taking any medication or taking salicylates, prednisone ( dose≤ 15mg and at least have taken a month ), after entering the study the dose remained constant;
• Not taking immunosuppressive agents or use " with " biological preparations within 3 months prior to entering the study
• signing a written informed consent form.

Exclusion Criteria:

• Severe Crohn's disease patients or patients in remission ( CDAI > 450 or < 150 );
• The pregnancy or lactation period patients ;
• patients associated with heart, brain, liver, kidney and hematopoietic system disease;
• The psychiatric patients;
• Patients with other serious diseases.