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| Name | Class |
|---|---|
| University of Lausanne Hospitals | OTHER |
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Comparison of the ability of a new automated ventilatory mode named Intellibrain to maintain capnia and oxgen partial pressure within predefined ranges in comparison to the control of capnia and oxgen partial pressure obtained by using standard controlled ventilation modes in brain injured patients. Comparison of the numbers of alarms and required settings modifications observed with each ventilatory mode.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Standard mode of controlled ventilation | No Intervention | Each brain injured patient will be ventilated during two hours with a standard mode of controlled ventilation. | |
| Intellivent arm | Experimental | Each brain injured patient will be ventilated during two hours with an automated mode of ventilation, the Intellivent mode. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Intellivent | Device |
|
| Measure | Description | Time Frame |
|---|---|---|
| Partial pressure of carbon dioxide | The partial pressure of carbon dioxide (PaCO2) will be recorded every thirty minutes during 2 hours under standard controlled ventilation and during 2 hours under Intellivent ventilation |
| Measure | Description | Time Frame |
|---|---|---|
| Partial pressure of oxygen | The partial pressure of oxygen (PaCO2) will be recorded every thirty minutes during 2 hours under standard controlled ventilation and during 2 hours under Intellivent ventilation | |
| Number of alarms generated by the ventilator |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Philippe Jolliet, Prof | University of Lausanne Hospitals | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Adult Intensive Care and Burn Unit, University hospital of Lausanne | Lausanne | 1012 | Switzerland |
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| ID | Term |
|---|---|
| D001930 | Brain Injuries |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D006259 | Craniocerebral Trauma |
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The number of alarms generated by the ventilator will be recorded during 2 hours under standard controlled ventilation and during 2 hours under Intellivent ventilation |
| Number of settings modifications | The number of ventilator settings modifications required will be recorded during 2 hours under standard controlled ventilation and during 2 hours under Intellivent ventilation |
| Intracranial pressure | Intracranial pressure will be recorded continuously during 2 hours under standard controlled ventilation and during 2 hours under Intellivent ventilation |
| Respiratory parameters | Various respiratory parameters tidal volume, respiratory rate, minute ventilation, airway pressure) will be recorded during 2 hours under standard controlled ventilation and during 2 hours under Intellivent ventilation |
| Cerebral vasoreactivity | Cerebral vasoreactivity will be studied from the intracranial pressure and invasive arterial pressure curves recorded during 2 hours under standard controlled ventilation and during 2 hours under Intellivent ventilation |
| Partial pressure of oxygen in the brain tissue if available | Partial pressure of oxygen in the brain tissue, if available for clinical reasons, will be recorded during 2 hours under standard controlled ventilation and during 2 hours under Intellivent ventilation |
| Number of therapeutic actions needed to reduce intracranial pressure | The number of therapeutic actions needed to reduce intracranial pressure will be recorded during two hours under standard controlled ventilation and during two hours under Intellivent ventilation. |
| Cerebral perfusion pressure | Cerebral perfusion pressure will be recorded continuously during 2 hours under standard controlled ventilation and during 2 hours under Intellivent ventilation |
| D020196 | Trauma, Nervous System |
| D014947 | Wounds and Injuries |