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This is a 12-week open label trial to evaluate whether omega-3 fatty acids is effective in reducing the severity of autism and its comorbidities.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Omega-3 Fatty Acids | Experimental | 15ml omega-3 liquid form, twice a day for 12 weeks (Total daily dosage:840mg DHA and 192mg EPA) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Omega-3 fatty acids | Dietary Supplement |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in parent rated Social Responsiveness Scale (SRS) scores during treatment | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in parent rated Child Behavior Checklist (CBCL) scores during treatment | 12 weeks | |
| Change from baseline in teacher rated Teacher Report (TRF) scores during treatment | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Assessment of plasma fatty acid composition, measurements of DHA and EPA (components of omega-3), and total phospholipid count | 12 weeks | |
| Assessment of dietary intake and nutritional intake of the child | 12 weeks |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Min Sung, MBBS, MMed | National Healthcare Group, Singapore | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institute of Mental Health | Singapore | 168937 | Singapore |
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| ID | Term |
|---|---|
| D000067877 | Autism Spectrum Disorder |
| ID | Term |
|---|---|
| D002659 | Child Development Disorders, Pervasive |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D015525 | Fatty Acids, Omega-3 |
| ID | Term |
|---|---|
| D004042 | Dietary Fats, Unsaturated |
| D004041 | Dietary Fats |
| D005223 | Fats |
| D008055 | Lipids |
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| Change from baseline in teacher rated Social Responsiveness Scale (SRS) scores during treatment | 12 weeks |
| Change from baseline in clinician rated Clinical Global Impression (Severity and Improvements) scores during treatment | 12 weeks |
| Change from baseline in clinician rated Global Assessment of Functioning (GAF) scores during treatment | 12 weeks |
| Children's Yale-Brown Obsessive Compulsive Scale modified for Pervasive Developmental Disorders (CYBOCS-PDD) | 12 weeks |
| D005231 |
| Fatty Acids, Unsaturated |
| D005227 | Fatty Acids |
| D005395 | Fish Oils |
| D009821 | Oils |