Non-invasive Assessment of Intraocular Pressure in MPS by Use of the Ocular Response Analyzer.

Corneal-Compensated Intraocular Pressure, Corneal Hysteresis and Corneal Resistance Factor Measurements Performed With the Ocular Response Analyzer and Their Correlation to Conventional Goldmann Applanation Tonometry.

The aim of the present study is to compare intraocular pressure (IOP) values assessed with Ocular Response Analyzer to the classical gold standard of IOP measurement, to Goldmann applanation tonometry by mucopolysacchyridosis-, Fabry-patients and healthy controls. We want to investigate biomechanical characteristics of the cornea and their influence on the IOP-measurements.

Inclusion Criteria:

• MPS I, II, IV, VI patients with at least grade 3 of corneal clouding (Couprie et al.)
• Fabry patients with cornea verticillata > grade 1
• Age ≥ 12 years
• Patient is able to comply with the study procedure
• Patient has consented to be in the trial
• Ability to fixate a target

Exclusion Criteria:

• History of corneal transplantation or refractive surgery
• Corneal pathologies other than MPS-associated corneal opacity
• Corneal, conjunctival or intraocular inflammation