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The aim of this study is to evaluate the use of autologous expanded mesenchymal stem cells intralesional transplantation as a safe and potentially beneficial treatment for patients with spinal cord injury.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mesenchymal Stem cells | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Autologous Mesenchymal Stem Cells | Procedure | Expanded Intralesional Autologous Mesenchymal Stem Cells Transplantation |
|
| Measure | Description | Time Frame |
|---|---|---|
| Safety of Autologous Expanded Mesenchymal Stem Cells transplantation in SCI patients | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Functional improvement in muscle strength | According to motor index score | 1 year |
| Functional Improvement in sphincters control | 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Andrés ChahÃn, MD | ClÃnica Las Condes, Santiago | Principal Investigator |
| Rodrigo M Mardones, MD | ClÃnica Las Condes, Santiago | Study Director |
| Catalina Larrain, MD | ClÃnica Las Condes, Santiago | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| ClÃnica Las Condes | Santiago | RM | 7591468 | Chile |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19903102 | Result | Pal R, Venkataramana NK, Bansal A, Balaraju S, Jan M, Chandra R, Dixit A, Rauthan A, Murgod U, Totey S. Ex vivo-expanded autologous bone marrow-derived mesenchymal stromal cells in human spinal cord injury/paraplegia: a pilot clinical study. Cytotherapy. 2009;11(7):897-911. doi: 10.3109/14653240903253857. | |
| 21303266 | Result |
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| ID | Term |
|---|---|
| D013119 | Spinal Cord Injuries |
| ID | Term |
|---|---|
| D013118 | Spinal Cord Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D020196 | Trauma, Nervous System |
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| Functional improvement in spasticity control | 1 year |
| Ra JC, Shin IS, Kim SH, Kang SK, Kang BC, Lee HY, Kim YJ, Jo JY, Yoon EJ, Choi HJ, Kwon E. Safety of intravenous infusion of human adipose tissue-derived mesenchymal stem cells in animals and humans. Stem Cells Dev. 2011 Aug;20(8):1297-308. doi: 10.1089/scd.2010.0466. Epub 2011 Mar 17. |
| 16793729 | Result | Moviglia GA, Fernandez Vina R, Brizuela JA, Saslavsky J, Vrsalovic F, Varela G, Bastos F, Farina P, Etchegaray G, Barbieri M, Martinez G, Picasso F, Schmidt Y, Brizuela P, Gaeta CA, Costanzo H, Moviglia Brandolino MT, Merino S, Pes ME, Veloso MJ, Rugilo C, Tamer I, Shuster GS. Combined protocol of cell therapy for chronic spinal cord injury. Report on the electrical and functional recovery of two patients. Cytotherapy. 2006;8(3):202-9. doi: 10.1080/14653240600736048. |
| D014947 | Wounds and Injuries |