the study compare the hormonal-metabolic and reproductive outcome between combined metformin-letrozole and ovarian drilling in clomiphene resistant women with polycystic syndrome

Inclusion Criteria:

• polycystic ovary syndrome
• infertility
• clomiphene citrate resistance

Exclusion Criteria:

• women with other causes of infertility as male factor or tubal factor, those with endocrine disorders as thyroid dysfunction and hyperprolactinemia women who received hormonal treatment or ovulation induction drugs 3 months prior to the study
• pregnancy during follow up