Formation of Antibodies and Subsequent Prediction of Clinical Response in Patients With Rheumatoid Arthritis Treated With Four TNF Blocking Agents

Formation Of Antibodies And Subsequent Prediction Of Clinical Response In Patients With Rheumatoid Arthritis Treated With Four Tnf Blocking Agents

The rationale for this study is to further explore if development of antibodies against TNF-α blocking agents is associated with reduced clinical effect/worsened clinical outcome. An important aspect of the study is to carry out an exploratory analysis of the immunogenicity of the 4 recommended TNF-α blockers in the treatment of RA in Denmark, using the same cell-based assay.

no sampling

Inclusion Criteria:

• Subject fulfils criteria for Rheumatoid Arthritis (RA) according to ACR or EULAR criteria.
• Subjects who are planned to start treatment with ADA, ETA, CER or IFX
• Subjects taking a minimum weekly dose of 7.5 mg of methotrexate

Exclusion Criteria:

• Patients with compliance problems
• Patients who have difficulties in reading and understanding local language
• Patients with Juvenile Idiopathic Arthritis (JIA)
• Azathioprine or cyclophosphamide treatment within 6 months before entering into the study