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| ID | Type | Description | Link |
|---|---|---|---|
| 2011-005522-22 | EudraCT Number |
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| Name | Class |
|---|---|
| Oulu University Hospital | OTHER |
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We are investigating the effects of pregnane X receptor (PXR) activation on the regulation of blood pressure in healthy volunteers. Rifampicin (an antibiotic and also an efficient PXR activator) and placebo will be given for a week to volunteers and blood pressure is measured 24 hours using an ambulatory blood pressure monitor. Blood pressure regulating hormones will be measured in blood. Our hypothesis is that PXR is involved in the regulation of blood pressure.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Rifampicin | Active Comparator | Rifampicin 600 mg daily |
|
| Placebo | Placebo Comparator | Placebo daily |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Rifampicin | Drug |
|
| |
| Placebo |
| Measure | Description | Time Frame |
|---|---|---|
| Systolic ambulatory blood pressure | Systolic blood pressure measured with ambulatory blood pressure monitor. | On day 8 of each arm |
| Diastolic ambulatory blood pressure | Diastolic blood pressure measured with ambulatory blood pressure monitor | On day 8 of each arm |
| Measure | Description | Time Frame |
|---|---|---|
| Systolic and diastolic blood pressure | On day 9 of each arm | |
| Pulse (ambulatory) | On day 8 of each arm | |
| Plasma renin activity |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Janne Hukkanen, MD, PhD | Oulu University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Oulu University Hospital | Oulu | Finland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41744113 | Derived | Rahunen R, Merikallio H, Rinne V, Savolainen MJ, Hukkanen J. Hypertension in Overweight and Obesity: Sex-Specific Role of 4beta-Hydroxycholesterol. J Am Heart Assoc. 2026 Mar 3;15(5):e043913. doi: 10.1161/JAHA.125.043913. Epub 2026 Feb 26. | |
| 35229613 | Derived | Rahunen R, Kummu O, Koivukangas V, Hautajarvi H, Hakkola J, Rysa J, Hukkanen J. Pregnane X Receptor-4beta-Hydroxycholesterol Axis in the Regulation of Overweight- and Obesity-Induced Hypertension. J Am Heart Assoc. 2022 Mar 15;11(6):e023492. doi: 10.1161/JAHA.121.023492. Epub 2022 Mar 1. |
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| ID | Term |
|---|---|
| D012293 | Rifampin |
| ID | Term |
|---|---|
| D012294 | Rifamycins |
| D006576 | Heterocyclic Compounds, 4 or More Rings |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
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| Drug |
|
| On day 9 of each arm |
| Serum aldosterone | On day 9 of each arm |
| D047029 | Lactams, Macrocyclic |
| D047028 | Macrocyclic Compounds |
| D011083 | Polycyclic Compounds |