(i) To compare a new diagnostic PCR with established diagnostic procedures for T. pallidum (serology, dark field microscopy), H. ducreyi (cultivation), HSV types 1 and 2 (cultivation, PCR).

(ii) To assess the frequency of infections with T. pallidum, H. ducreyi and HSV types 1 and 2 in patients with genital, anal and oropharyngeal ulcers by a new PCR.

Inclusion criteria:

• Patient with genital, anal or oropharyngeal ulcers
• Age minimum of 18 years.
• Informed consent must be obtained from each patient/control patient in written form prior to any study procedure.

Exclusion criteria:

• Antibiotic therapy within 2 weeks before the visit

Patient with genital, anal or oropharyngeal ulcers