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| Name | Class |
|---|---|
| Hunan University of Traditional Chinese Medicine | OTHER |
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This trail aims to evaluate the efficacy of acupoints on the specific meridian for chronic stable angina pectoris, compared with acupoints on the other meridian, sham acupoints and waiting-list. And to confirm the specificity of acupoints on meridian.
The basis of acupuncture is the theory of meridians and acupoints. Meridian and collaterals internally pertain to viscera, and externally spread over the extremities. An acupoint is the place where the visceral qi and meridian qi distributed in. besides acupoints are the stimulus points and reactive points for acupuncture to treat the diseases. Selecting the acupoints on the specific meridian is the basic principle of acupuncture. Recently, as to the existence of specificity of acupoints on the meridian has been questioned by many researchers. This trial using chronic stable angina pectoris as a carrier, select the acupoints on the hand shao yin heart meridian and hand jue yin pericardium meridian to treat chronic stable angina pectoris. Compared with acupoints on the other meridian and non-acupoints ,aiming to evaluate the efficacy, furthermore ,to confirm the existence of the specificity of acupoints on meridian.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| acupoints on specific meridian | Experimental | Acupuncture plus foundation treatment。 We Select specific acpupoints on the heart and pericardium meridian. |
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| acupoints on the other meridian | Active Comparator | Acupuncture plus foundation treatment。We choose the acupoints on the other meridian。 |
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| sham acupoints | Sham Comparator | Acupuncture plus foundation treatment。We use sham acupoints。 |
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| waiting-list | Other | wait for the treatment,Only basic treatment, We will not treat the participants until they complete all the observations. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| acupuncture | Other | In each session, we treat bilaterally, 3 times a week and 2 days off a week, each patient in the acupuncture treatment groups will receive 12 sessions of acupuncture treatment over 4 weeks. The whole study period is 20 weeks including 4-week baseline period,4-week treatment period, and 12-week follow-up period. we will investigate at 0 day,4week,8week,12week,16week after randomization。 |
| Measure | Description | Time Frame |
|---|---|---|
| Number of angina attacks | The frequency of angina attack during 4-week. | 16 weeks after inclusion |
| Measure | Description | Time Frame |
|---|---|---|
| The severity of angina ( VAS score) | The VAS score evaluation angina pain severity | 0 day,4, 8, 12, 16 weeks after inclusion |
| The dosage of nitroglycerin | 0 day,4, 8, 12, 16 weeks after inclusion |
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Inclusion Criteria:
1.Meet the diagnostic criteria of ACC/AHA angina pectoris of coronary heart disease.
2.35 ≤ age ≤ 80 years of age, both male and female.
3.The onset of angina pectoris≥3 months, and the frequency of angina attack≥2 a week.
4.Patients signed the informed consent.
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| fan-rong liang, Professor | Chengdu University of Traditional Chinese Medicine | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chengdu University of Traditional Chinese Medicine | Chengdu | Sichuan | 610075 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31355870 | Derived | Zhao L, Li D, Zheng H, Chang X, Cui J, Wang R, Shi J, Fan H, Li Y, Sun X, Zhang F, Wu X, Liang F. Acupuncture as Adjunctive Therapy for Chronic Stable Angina: A Randomized Clinical Trial. JAMA Intern Med. 2019 Oct 1;179(10):1388-1397. doi: 10.1001/jamainternmed.2019.2407. | |
| 24499445 | Derived | Li D, Yang M, Zhao L, Zheng H, Li Y, Chang X, Cui J, Wang R, Shi J, Lv J, Leng J, Li J, Liang F. Acupuncture for chronic, stable angina pectoris and an investigation of the characteristics of acupoint specificity: study protocol for a multicenter randomized controlled trial. Trials. 2014 Feb 5;15:50. doi: 10.1186/1745-6215-15-50. |
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| ID | Term |
|---|---|
| D060050 | Angina, Stable |
| D000787 | Angina Pectoris |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
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| ID | Term |
|---|---|
| D015670 | Acupuncture Therapy |
| ID | Term |
|---|---|
| D000529 | Complementary Therapies |
| D013812 | Therapeutics |
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| Basic treatment | Drug | Each group in the basic treatment,Foundation treatment including health education and basic drug therapy. We recommend lifestyle modification for all patients. Modifications include increasing exercise; limiting alcohol consumption; and weight loss; quit smorking etc. Basic medication: Aspirin: 100mg qd; Metoprolol:25mg bid; Ramipril:5mg qd; Atorvastatin:20mg qn. |
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| Six minute walk test | Six minute walk test in the evaluation of exercise tolerance | 0 day and 4 weeks after inclusion |
| Dynamic ECG Observation of the changes of ST-T | Dynamic electrocardiogram in six minute walk test to do | 0 day and 4 weeks after inclusion |
| The Seattle Angina Questionnaire ( SAQ ) score | 0 day,4, 8, 12, 16 weeks after inclusion |
| self-rating anxiety scale | 0 day,4, 8, 16 weeks after inclusion |
| The incidence of cardiovascular episode during the 4 months | The incidence of cardiovascular episode during the 4 months(develop into unstable angina, acute myocardial infarction, death) | 4, 8, 12, 16 weeks after inclusion |
| Self-rating Depression Scale | 0 day,4, 8, 16 weeks after inclusion |
| D002637 |
| Chest Pain |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |