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| Name | Class |
|---|---|
| Onze Lieve Vrouw Hospital | OTHER |
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In this study the investigators compare the traditional way of triggering with a new way in patients with Poly Cystic Ovary Syndrome (PCOS). This to reduce the risque of Ovary Hyper Stimulation Syndrome (OHSS) in In Vitro Fertilization/ IntraCytoplastic Sperm Injection (IVF/ ICSI) treatment. The investigators also compare the number of mature oocytes, embryo's and pregnancy rate.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| humaan chorion gonadotropine | No Intervention | ovulation induction with 5000E hCG | |
| GnRH agonist + 1500E hCG | Active Comparator | ovulation induction with GnRH agonist and 1500E hCG one hour after egg retrieval |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| GnRh agonist +1500E hCG | Drug | ovulation induction with GnRh agonist and 1500E hCG one hour after egg retrieval |
|
| Measure | Description | Time Frame |
|---|---|---|
| MII oocytes | The number of mature oocytes retrieved after stimulation without creating OHSS | patients will be followed during the stimulation with an average of 10 days |
| 2 Pro Nuclei (2PN) fertilization | laboratory follow up of the fertilized egg during the first 24h | 24h after ICSI |
| Measure | Description | Time Frame |
|---|---|---|
| implantation rate | The number of pregnancies obtained wich still is the most important issue for the patients | 12 weeks |
| OHSS | patient follow up according to subjective complaints and objective measures |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Wim Decleer, gynecologist | IVF Centrum Jan Palfijn Gent | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| AZ Jan Palfijn | Ghent | Oost-vlaanderen | 9000 | Belgium |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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| one month with oocyte retrieval in the middle |