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The purpose of this study is to see whether the ICDs(Impulse Control Disorder) are improved and neuropsychiatric traits related to ICD are changed or not when switching dopamine agonist to levodopa/carbidopa in patients with Parkinson's disease who have been treated with dopaminergic medications.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Levodopa/Carbidopa(200mg/50mg) | Experimental |
| |
| Control A (dopaminergic agonist ) | Experimental | Parkinson patients treated with anti-Parkinson drug over 6 months. |
|
| Control B (no drug) | No Intervention | Parkinson diseased patients not treated. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Levodopa/Carbidopa(200mg/50mg) | Drug |
| ||
| Dopaminergic Agonists |
| Measure | Description | Time Frame |
|---|---|---|
| mMIDI(modified Minnesota Impulsive Disorders Interview) | To evaluate the improvement of mMIDI(Korean version) score from the baseline to 12 weeks or LOCF(Last Observation Carried Forward) | 12weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Neuropsychiatric profile | To evaluate the improvement of neuropsychiatric profiles from the baseline to 12 weeks or LOCF * Neuropsychological assessment
|
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jinwhan Cho, MD | Samsung Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sandoz Investigative Site | Anyang | South Korea | ||||
| Sandoz Investigative Site |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30361296 | Derived | Lee JY, Jeon B, Koh SB, Yoon WT, Lee HW, Kwon OD, Kim JW, Kim JM, Ma HI, Kim HT, Baik JS, Cho J; (REIN-PD Investigators). Behavioural and trait changes in parkinsonian patients with impulse control disorder after switching from dopamine agonist to levodopa therapy: results of REIN-PD trial. J Neurol Neurosurg Psychiatry. 2019 Jan;90(1):30-37. doi: 10.1136/jnnp-2018-318942. Epub 2018 Oct 25. |
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| ID | Term |
|---|---|
| D007174 | Disruptive, Impulse Control, and Conduct Disorders |
| ID | Term |
|---|---|
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D007980 | Levodopa |
| D002230 | Carbidopa |
| D018491 | Dopamine Agonists |
| ID | Term |
|---|---|
| D004295 | Dihydroxyphenylalanine |
| D002395 | Catecholamines |
| D000588 | Amines |
| D009930 | Organic Chemicals |
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| Drug |
Treated for at least 6 months after diagnosis of Parkinson's Disease. |
|
| 12 weeks |
| Daegu |
| South Korea |
| Sandoz Investigative Site | Pusan | South Korea |
| Sandoz Investigative Site | Seongnam | South Korea |
| Sandoz Investigative Site | Seoul | South Korea |
| D002396 |
| Catechols |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D010649 | Phenylalanine |
| D024322 | Amino Acids, Aromatic |
| D000598 | Amino Acids, Cyclic |
| D000596 | Amino Acids |
| D000602 | Amino Acids, Peptides, and Proteins |
| D014443 | Tyrosine |
| D008750 | Methyldopa |
| D006834 | Hydrazines |
| D015259 | Dopamine Agents |
| D018377 | Neurotransmitter Agents |
| D045504 | Molecular Mechanisms of Pharmacological Action |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
| D045505 | Physiological Effects of Drugs |