Corneal Cross Linking and Topography Guided Excimer Laser Treatment

Topography Guided Excimer Laser Surface Ablation in Combination With Corneal Cross-linking (CCL) in Patients With Progressive Ectatic Corneal Disorders.

Topography guided laser treatment enables the surgeon to correct higher order aberrations in corneas with irregular astigmatism. Several case reports and small uncontrolled trials have been published on the combination of this treatment with corneal cross linking (CCL) in patients with ectatic corneal diseases.

This randomized study will evaluate the safety and efficacy of a combined treatment of corneal cross linking with a partial topography guided excimer laser treatment in eyes with progressive ectatic corneal diseases.

Inclusion Criteria:

• Signed informed consent
• Patient age 18 - 40 years
• Documented progressive corneal ectatic disease except post LASIK/LASEK ectasia

Exclusion Criteria:

• Allergy to one of the used substances
• Tendency towards excessive scar formation
• Pregnancy
• Rheumatic diseases
• Central corneal thickness below 450 µm
• Active infection of the study eye
• Previous corneal surgery of the study eye