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Topography guided laser treatment enables the surgeon to correct higher order aberrations in corneas with irregular astigmatism. Several case reports and small uncontrolled trials have been published on the combination of this treatment with corneal cross linking (CCL) in patients with ectatic corneal diseases.
This randomized study will evaluate the safety and efficacy of a combined treatment of corneal cross linking with a partial topography guided excimer laser treatment in eyes with progressive ectatic corneal diseases.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Corneal Cross Linking | Active Comparator | Patients will receive a standard corneal cross linking treatment |
|
| Corneal Cross Linking and Topo Laser | Experimental | Patients will receive a topography guided laser treatment in combination with a standard corneal cross linking treatment in the same session. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Topography guided Excimer Laser treatment and Corneal Cross Linking | Other | A topography guided excimer laser treatment will be performed prior to CCL in one session. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Safety (Pachymetry, K-readings) | 1 year | |
| uncorrected visual acuity (UVCA) | 1 year | |
| best corrected visual acuity (BCVA) | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Progression of ectatic disease (by use of maximum keratometry readings = Kmax) | 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical University of Vienna, Department of Ophthalmology | Vienna | 1090 | Austria |
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| ID | Term |
|---|---|
| D007640 | Keratoconus |
| ID | Term |
|---|---|
| D003316 | Corneal Diseases |
| D005128 | Eye Diseases |
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| ID | Term |
|---|---|
| D000094504 | Corneal Cross-Linking |
| ID | Term |
|---|---|
| D010778 | Photochemotherapy |
| D003131 | Combined Modality Therapy |
| D013812 | Therapeutics |
| D004358 | Drug Therapy |
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| Corneal Cross Linking | Other | A standard corneal cross linking procedure will be performed in this arm. |
|
| D010789 |
| Phototherapy |